瘤微环境通过癌症衍生的细胞外囊泡进行调节
Artem Ten1, Vadim Kumeiko1, Vladislav Farniev1
1School of Medicine and Life Sciences, Far Eastern Federal University, 690922 Vladivostok, Russia.
Cells
|April 26, 2024
概括
瘤微环境细胞和瘤细胞衍生的细胞外囊泡 (EVs) 驱动癌症的进展和治疗阻力. 本综述探讨了包括外体在内的EV如何转化正常细胞并影响癌症诊断和治疗.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 生物化学 生化学
背景情况:
- 瘤微环境 (TME) 对瘤产生至关重要,它影响癌细胞的生长,代谢,入侵和对治疗的抵抗力.
- 关键的TME细胞,如与癌症相关的纤维细胞 (CAF),与瘤相关的巨细胞 (TAM),中性粒细胞和自然杀手细胞 (NK) 调节瘤的进展和异质性.
- 瘤细胞衍生的细胞外囊泡 (EVs) 越来越多地被认可,因为它们在TME中将正常细胞转化为原始细胞的对应物中的作用.
研究的目的:
- 审查细胞外囊泡 (EVs) 在调节瘤微环境 (TME) 中的多方面的功能.
- 阐明外体细胞对TME内的正常细胞转化有所贡献的特定机制.
- 突出EVs在癌症管理中的诊断和治疗潜力.
主要方法:
- 文献综述侧重于细胞外囊泡 (EV) 在瘤微环境 (TME) 中的作用.
- 对研究EV介导的分子 (RNA,蛋白质,脂质) 转移及其对细胞表型的影响进行分析.
- 综合目前对外体的研究及其对癌症进展和异质性的贡献.
主要成果:
- 细胞外囊泡 (EVs) 在TME中调解细胞间通信,促进癌细胞的增殖,转移和免疫逃逸.
- 电子细胞,特别是外体细胞,有助于将正常的树皮细胞重新编程成与癌症相关的纤维细胞 (CAF) 和与瘤相关的巨细胞 (TAM).
- EVs的分子载荷影响瘤异质性和对化学辐射疗法等常规癌症治疗方法的耐药性.
结论:
- 细胞外囊泡 (EVs) 是塑造瘤微环境 (TME) 和推动癌症发展的关键影响者.
- 了解EV功能,特别是外体,为癌症诊断和开发向治疗提供了新的策略.
- 针对EV介导的沟通提供了一条有希望的途径,可以克服治疗耐药性并改善患者的治疗结果.
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