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口腔平坦菌中的微生物概况:与健康对照和侵蚀性与非侵蚀性亚型的比较
Hye-Min Ju1,2, Yong-Woo Ahn1,2, Soo-Min Ok1,2
1Department of Oral Medicine, Dental and Life Science Institute, School of Dentistry, Pusan National University, Busandaehak-ro 49, Mulgeum-eup, Yangsan 50612, Republic of Korea.
Diagnostics (Basel, Switzerland)
|April 26, 2024
概括
与健康个体相比,口腔平坦 (OLP) 患者表现出不同的口腔微生物组概况. 在侵蚀性和非侵蚀性OLP之间也观察到差异,这表明细菌可能有助于OLP的发病.
科学领域:
- 口腔微生物学 口腔微生物学
- 免疫皮肤学 免疫皮肤学
- 微生物组研究的研究.
背景情况:
- 口腔平坦 (OLP) 是一种具有不明原因的炎症状况.
- 新出现的证据表明,口腔微生物群在OLP病变发生过程中起着作用.
- 对OLP亚型和健康对照的全面比较研究是有限的.
研究的目的:
- 将OLP (侵蚀性和非侵蚀性亚型) 患者的唾液微生物概况与健康对照 (HC) 进行比较.
- 调查侵蚀性 (E-OLP) 和非侵蚀性 (NE-OLP) OLP之间的口腔微生物组合的潜在差异.
- 确定与OLP相关的特定细菌种群.
主要方法:
- 从60名OLP患者 (25名E-OLP,35名NE-OLP) 和30名HC患者收集的唾液样本.
- 使用16S rRNA基因测序 (隐含) 分析的微生物组组成.
- 评估了α多样性 (Chao1,Shannon指数) 和β多样性 (Bray-Curtis距离).
主要成果:
- 在HC,E-OLP和NE-OLP组之间,α多样性没有显著差异.
- 在HC和E-OLP和NE-OLP两组之间微生物组组成分布的显著差异 (Bray-Curtis).
- 在OLP群体中,Bacteroidetes的流行率更高;在OLP中,Prevotella是占主导地位的属.
- 与NE-OLP相比,Capnocytophaga在E-OLP中显示出更高的流行率.
结论:
- 在OLP患者和健康对照者之间,口腔微生物群组成存在显著差异.
- 在侵蚀性和非侵蚀性OLP亚型之间,可以识别出不同的微生物组概况.
- 增加特定口腔细菌的丰富性可能会导致OLP炎症并充当抗原.
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