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从使用非斯托克斯拖动系数的沉积实验中确定粉水凝微球的密度

Margherita Cretella^1,2,3, Mina Fazilati^1,2, Nedim Krcic⁴

¹Department of Biomedical Science, Malmö University, 20506 Malmö, Sweden.

Gels (Basel, Switzerland)

|April 26, 2024

概括

粉微球的沉积因流而偏离斯托克斯定律. 非斯托克斯阻力系数对于涉及这些制药颗粒的准确计算是必要的.

科学领域:

合体和制药科学药物科学
材料科学材料科学材料科学

背景情况:

沉在制药配方设计中至关重要.
斯托克斯定律,假设分层流,通常用于描述沉积.
了解不同介质中的粒子行为至关重要.

研究的目的:

为了研究交叉连接的无形粉微球的膨胀和水合.
确定适当的模型来计算沉积速度和颗粒密度.
评估pH值和盐度对粉微球特性的影响.

主要方法:

研究了纯水中的粉微球,NaCl溶液和经pH调整的水溶液.
计算了雷诺斯数来描述流体流动的情况.
根据实验观测和液体特性确定颗粒密度.

主要成果:

雷诺兹数表示了层状流和流之间的过渡状态.
对于沉积计算,建议使用非斯托克斯阻力系数表达式.
水中的粉微粒密度约为1050kg/m3.
颗粒密度随着周围液体的密度而变化.
密度表示的微球膨胀,在测试范围内对pH和盐度不敏感.

结论:

标准斯托克斯定律不足以描述粉微球沉积.
准确的药物配方分析需要非斯托克斯流体动力学模型.
交联的粉微球在不同的pH值和盐度中表现出稳定的膨胀特征.

关键词:

交叉连接的粉水凝.非斯托克斯的拖拉机沉积的沉积方式粉微粒粉微粒的微粒

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