相关实验视频

Updated: Jun 27, 2025

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

怀孕对乳腺癌特征和预后的影响

Valentina E Bounous¹, Carola Minella¹, Luca Fuso¹

¹Gynecology and Obstetrics Unit, Umberto I Hospital, Department of Surgical Sciences, University of Turin, Largo Turati 62, 10128 Turin, Italy.

Current oncology (Toronto, Ont.)

|April 26, 2024

概括

与怀孕相关的乳腺癌 (PABC) 似乎不是一种独立的不良预后因素,用于无病生存 (DFS). 节点参与仍然是乳腺癌年轻女性DFS的主要负面预测因素.

科学领域:

在瘤学瘤学.
生殖健康生殖健康
医学统计医学统计

背景情况:

与怀孕相关的乳腺癌 (PABC) 很少见,每3000例怀孕中就有1例发生.
PABC通常呈现出侵略性特征,需要对其预后影响进行进一步调查.

研究的目的:

评估怀孕对年轻女性乳腺癌预后的影响.
为了比较无病生存期 (DFS) 在无孕妇女,PABC妇女和怀孕后确诊的乳腺癌妇女中.

主要方法:

在1995年至2019年期间接受治疗的282名年轻乳腺癌 (BC) 患者 (≤45岁) 的回顾性分析.
患者被分为无卵性,PABC (在怀孕2年内诊断) 和怀孕后的BC组.
分析包括组织学因素,手术类型,复发和DFS,以及单变量和多变量统计评估.

主要成果:

诊断时的年龄较小的女性观察到,与女性相比,无阴性妇女的年龄较小 (p < 0.001).
两组之间没有发现组织学特征或复发率的显著差异.
在多变量分析中,节点参与 (OR=2.4,p<0.0001) 是DFS的唯一独立负预后因素,而怀孕本身并没有显著影响DFS (OR=0.8,p=0.30).

结论:

怀孕不是乳腺癌无病生存的独立不良预后因素.
节点参与是诊断为乳腺癌的年轻女性中更糟糕的DFS的关键独立预测因素.

关键词:

乳腺癌乳腺癌乳腺癌怀孕怀孕怀孕怀孕怀孕与怀孕相关的乳腺癌 (PABC)预后预后预后

更多相关视频

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose

Published on: October 14, 2015

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

相关概念视频

Cancer Survival Analysis

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Disorders of the Female Reproductive System

Disorders of the Female Reproductive System

The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

Pathophysiology of Diabetes

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...

Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...