Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

178
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
178
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

45.9K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Is the HIV-2 pandemic going extinct 40 years after virus discovery?

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi·2026
Same author

HIV-2 infection in Europe - persistence by migrant flows from West Africa but low spillover into the native population.

Le infezioni in medicina·2026
Same author

Roxadustat in lupus nephritis: a novel therapeutic signal for multifactorial anaemia.

Lupus science & medicine·2026
Same author

Trends in hospitalizations in adults with HIV infection in Spain over 25 years.

Pathogens and global health·2026
Same author

Infection With Human T-Lymphotropic Virus 1 (HTLV-1) in Ivory Coast.

Journal of medical virology·2026
Same author

HTLV-1 genetic diversity of 52 complete sequences from 14 African countries reveals novel variants and a lack of typical P12/P8 and P30 accessory proteins in HTLV-1b, d, and f genotypes.

Emerging microbes & infections·2026

相关实验视频

Updated: Jun 27, 2025

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
07:25

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

6.9K

全球控制乙型肝炎的前景

Vicente Soriano1, Víctor Moreno-Torres1,2, Ana Treviño1

  • 1UNIR Health Sciences School & Medical Center, 28010 Madrid, Spain.

Pathogens (Basel, Switzerland)
|April 26, 2024
PubMed
概括

乙型肝炎病毒 (HBV) 感染是全球卫生危机. 新疗法旨在实现功能性治疗,但终身治疗和疫苗接种是消除HBV的关键.

关键词:
布莱维尔提德 (Bulevirtide) 是一种蛋白质的化合物.慢性乙型肝炎 慢性乙型肝炎恩特卡维尔 (Entecavir) 是一种药物.基因编辑 基因编辑甲型肝炎 甲型肝炎 甲型肝炎长期作用的抗病毒药物这种药物是tenofovir.

更多相关视频

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
11:34

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

2.2K
Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
04:11

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection

Published on: December 15, 2023

3.3K

相关实验视频

Last Updated: Jun 27, 2025

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
07:25

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

6.9K
A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
11:34

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

2.2K
Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
04:11

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection

Published on: December 15, 2023

3.3K

科学领域:

  • 肝病学和病毒学.
  • 传染性疾病 传染性疾病
  • 公共卫生 公共卫生

背景情况:

  • 乙型肝炎病毒 (HBV) 感染影响全球超过2.5亿人,导致肝癌导致的死亡率很高.
  • 尽管有疫苗,但全球疫苗覆盖率仍不够理想,每年有150万例新感染,主要是通过成年人的性传播.
  • 目前的口服核胺类型可以实现病毒抑制,但很少能有效治愈,需要终身治疗.

研究的目的:

  • 审查B型肝炎病毒 (HBV) 管理的现状,并探索新兴的治疗策略.
  • 突出现有治疗方法的局限性和需要新的方法来实现慢性HBV的功能治疗.
  • 概述全球根除HBV的基本公共卫生行动.

主要方法:

  • 审查当前的抗病毒疗法,包括口服核胺类型 (恩特卡维尔,特诺福维尔).
  • 讨论正在开发的新型治疗药物 (进入抑制剂,囊组装调节器,RNA干扰).
  • 探索先进的策略,如组合疗法,基因编辑和对HBV基因组破坏的基因疗法.

主要成果:

  • 核胺模拟疗法导致大多数坚持患者无法检测的病毒病,但很少实现抗HBs血清转化或治愈.
  • 新兴疗法和组合策略的目标是功能性治疗 (负HBV-DNA和HBsAg),尽管ccccDNA储存库仍然存在.
  • 基因疗法有可能彻底破坏HBV基因组并完全治愈.

结论:

  • 目前需要终身抗病毒治疗,但新的长效配方和新型药物有望改善结果.
  • 实现功能性治疗仍然是一个目标,基因疗法显示出最终根除的希望.
  • 扩大新生儿疫苗接种,成人查和早期抗病毒治疗对于全球的HBV控制和消除至关重要.