来自断奶奶牛的呼吸道细菌中的抗菌素耐药性基因
Sarah Depenbrock1, Cory Schlesener2, Sharif Aly3
1Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA.
Pathogens (Basel, Switzerland)
|April 26, 2024
概括
抗微生物耐药性基因在导致乳牛牛的呼吸系统疾病的细菌中很常见. 这表明耐药性具有很高的遗传潜力,强调需要减少抗菌药物使用和预防疾病.
科学领域:
- 兽医微生物学 兽医微生物学
- 抗微生物耐药性 抗微生物耐药性
- 牛的呼吸道疾病 牛的呼吸道疾病
背景情况:
- 牛呼吸道疾病 (Bovine Respiratory Disease,BRD) 是一个主要的死亡原因和在断奶奶牛中使用抗菌药物 (AMD).
- 在这个特定人群中,呼吸道细菌对抗菌素耐药性 (AMR) 的数据有限.
研究的目的:
- 为了确定AMR基因存在于断奶奶牛的关键呼吸道细菌分离物中.
- 评估基因型AMR和表型耐药性之间的一致性.
- 为了确定流行AMR基因类和它们的共发生模式.
主要方法:
- 326个呼吸道分离物的全基因组测序 (Pasteurella multocida,Mannheimia haemolytica,Histophilus somni).这些分离物体的基因组测序包括:
- 在8个AMD类中识别和量化26个AMR基因.
- 基因型AMR基因存在与表型耐药性数据的比较.
主要成果:
- 检测到的AMR基因的高患病率为四环素 (95%),氨基糖化物 (94%),硫胺 (94%),β-乳酸胺 (77%),醇 (50%) 和类 (44%).
- 多个AMR基因在单个隔离物中频繁同时出现,使得对多个AMD类产生抗性.
- 可变的基因型-表型一致性,尤其是诺基诺和ceftiofur.
结论:
- 断奶的奶牛牛含有具有AMR显著遗传潜力的呼吸道细菌.
- 减少AMD的依赖和实施有效的BRD预防策略对于这一群体至关重要.
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