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婴儿的胰腺β细胞功能因母亲的体重而异

Lisa R Staimez^1,2, Anubrati Dutta³, Yara S Beyh¹

¹Emory Global Diabetes Research Center, Woodruff Health Sciences Center, Emory University, Atlanta, GA 30322, USA.

|April 26, 2024

概括

母体体重影响婴儿胰腺β细胞功能,显示出U形关系. 低体重和超重的母亲在出生时具有更高的婴儿β细胞功能,并在7个月后改变了胰岛素抵抗.

科学领域:

内分泌学在内分泌学.
儿科儿科儿科
孕产妇和胎儿医学孕产妇和胎儿医学

背景情况:

母亲的营养状况是胎儿发育和长期健康的关键决定因素.
婴儿胰腺β细胞功能和胰岛素抵抗是受到子宫内环境影响的关键代谢参数.

研究的目的:

调查母亲怀孕前体重类别与婴儿胰腺β细胞功能和产后7个月的胰岛素耐药性之间的关联.
探索母体体重和婴儿代谢适应之间的潜在U形关系.

主要方法:

印度海得拉巴的前性队列研究,涉及根据第一季度的BMI分类为体重不足 (UW),正常体重 (NW) 或超重 (OW) 的孕妇.
婴儿口服葡萄糖耐受性测试 (OGTT) 和血液C-/葡萄糖测试是在产后7个月后进行的.
婴儿β细胞功能 (HOMA2-B,处置指数 (DI)) 和胰岛素耐药性 (HOMA2-IR) 被计算并通过母体体重组进行比较.

主要成果:

婴儿带HOMA2-B显示出与母亲体重的U形关系,与NW相比,在UW和OW组显著高于NW组.
在母体体重组之间没有观察到婴儿HOMA2-IR出生时的显著差异.
在产后7个月,UW母亲的婴儿显示出最大的HOMA2-IR中位数减少,而OW母亲的婴儿显示出最小的.
7个月的婴儿倾向指数 (DI) 在UW组明显高于NW和OW组.

结论:

孕前母亲的体重会影响婴儿的胰腺β细胞功能和胰岛素敏感性,在低体重和超重母亲的婴儿中观察到明显的适应.
这些发现强调了母亲营养环境在规划婴儿代谢健康中的作用,这表明对葡萄糖平衡有潜在的长期影响.

关键词:

发展起源的发展起源婴儿时期的婴儿期胰腺β细胞的功能怀孕怀孕怀孕怀孕怀孕体重体重体重体重体重

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