FuncPEP v2.0:由非编码RNA翻译的功能短的更新数据库
Swati Mohapatra1,2, Anik Banerjee2,3, Paola Rausseo1,4
1Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Non-coding RNA
|April 26, 2024
概括
越来越多地发现了从非编码RNA (ncRNA) 翻译的功能性,称为ncPEPs. 更新的FuncPEP v2.0数据库现在包括152个ncPEP,突出了它们的双价生物作用.
科学领域:
- 分子生物学分子生物学
- 基因组学就是基因组学.
- 蛋白质组学是指蛋白质组学.
背景情况:
- 非编码RNAs (ncRNAs) 越来越多地被认为其作用超出了结构或调节功能.
- 短功能 (ncPEP) 可以从ncRNA中翻译,为这些转录呈现双价函数.
- 了解ncPEP对于推动生物和疾病研究至关重要.
研究的目的:
- 更新FuncPEP数据库以从ncRNAs (ncPEPs) 翻译的新发现的功能性.
- 将宿主ncRNA分类并分析新发现的ncPEPs的特征.
- 为研究ncPEP及其功能的研究人员提供全面的资源.
主要方法:
- 从2020年8月到2023年7月,使用特定的关键词进行了系统的PubMed搜索.
- 我们选了报告来自ncRNAs的验证功能的出版物.
- 来自已识别的ncPEPs的数据被编译和分类,包括宿主ncRNA类型,物种,识别方法和功能分布.
主要成果:
- FuncPEP v2.0数据库包含152个功能性ncPEP,在过去三年中发现了40个新项目.
- 观察到新发现的功能性ncPEPs的增加是稳定的,而不是显著的.
- 新发现的ncPEPs通过各种参数进行了表征,包括宿主ncRNA,物种,长度,识别方法和功能角色.
结论:
- 更新的FuncPEP v2.0数据库扩展了从ncRNAs中翻译的功能的知识.
- 虽然质谱学有助于ncPEP的识别,但在充分描述其功能方面仍然存在挑战.
- 需要进一步的研究来克服在证明已识别的ncPEPs的功能意义上的局限性.
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