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miRNAs作为肥胖和癌症之间的相互连接器
Grecia Denisse González-Sánchez1, Angelica Judith Granados-López2, Yamilé López-Hernández3
1Doctorate in Biosciences, University Center of Los Altos, University of Guadalajara, Tepatitlán de Morelos C.P. 47620, Mexico.
Non-coding RNA
|April 26, 2024
概括
肥胖和癌症风险与非编码RNA (ncRNA) 有关. 本综述探讨了微RNAs (miRNAs) 和长非编码RNAs (lncRNAs) 的失调如何将肥胖和癌症联系在一起,突出了它们作为生物标志物的潜力.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 肥胖是一个全球性的健康问题,与癌症风险增加有关.
- 非编码RNAs (ncRNAs) 在调解肥胖与癌症的联系中的作用尚未完全理解.
- ncRNAs,包括微RNAs (miRNAs) 和长非编码RNAs (lncRNAs),在细胞调节中至关重要.
研究的目的:
- 在肥胖和癌症中审查miRNAs和lncRNAs的失调.
- 阐明ncRNAs之间的相互作用及其在加剧肥胖相关癌症中的作用.
- 关于在肥胖和癌症中 lncRNA-miRNA 相互作用的 in silico 调查.
主要方法:
- 在肥胖和癌症中对miRNAs和lncRNAs的文献综述.
- 在线分析lncRNA和miRNA相互作用.
- 确定参与关键信号通路的特定miRNAs和lncRNAs.
主要成果:
- 在肥胖和癌症中确定了44个上调和49个下调的lncRNAs.
- 发现了特定miRNAs (例如miR-375,miR-130,miR-128-3p) 和参与PPARγ和MAPK信号传递的lncRNAs之间的相互作用.
- 突出了miRNA-lncRNA平衡在与肥胖相关的癌症发展中的关键作用.
结论:
- 失调的ncRNAs,特别是miRNAs和lncRNAs,在肥胖与癌症的联系中起着重要作用.
- 特定的miRNA-lncRNA相互作用调节与肥胖和癌症相关的关键细胞信号通路.
- ncRNAs显示为肥胖相关癌症的潜在生物标志物具有前途,需要进一步调查.
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