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尿液挥发性有机化合物代谢物与美国儿童和青少年的肺功能下降有关
Angelico Mendy1, Sara Burcham1, Ashley L Merianos2
1Division of Epidemiology, Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
暴露于常见的室内污染物,如烯,烯和氧化物,可能会对儿童的肺功能产生负面影响. 这项研究揭示了特定挥发性有机化合物 (VOC) 代谢物与年轻人肺容量减少之间的新相关性.
科学领域:
- 环境健康 环境健康
- 儿科肺病学 儿科肺病学
- 毒理学 毒理学 毒理学
背景情况:
- 挥发性有机化合物 (VOC) 是普遍存在的室内空气污染物.
- 吸入是VOC的主要暴露途径.
- 许多VOCs对儿科肺功能的影响仍未得到充分研究.
研究的目的:
- 调查尿液中VOC代谢物与儿童和青少年肺功能之间的关联.
- 确定可能对儿科患者的呼吸系统健康产生负面影响的特定VOCs.
主要方法:
- 来自2011-2012年国家健康和营养检查调查的505名6-17岁参与者的分析.
- 利用多个线性回归模型来评估VOC代谢物和螺旋计结果之间的关系.
- 经统计分析中的相关共变量调整.
主要成果:
- 在大多数参与者身上检测到烯胺,烯,氧化物,1-烯和甲的尿代谢物.
- 较高水平的烯胺和烯代谢物与预测的1秒内较低的强迫呼气体积 (FEV) %有关.
- 氧化代谢物的增加与FEV1/强迫生命能力 (FVC) 比率的降低相关.
- 对于克罗托纳尔化物 (超重/肥胖儿童) 和1-布罗莫 (具有较高可提宁水平的儿童) 与肺功能参数观察到显著的相互作用.
结论:
- 在儿童和青少年中,特定的VOC代谢物 (烯,氧化物,烯,1-烯,甲) 和肺功能下降之间发现了新的关联.
- 这些发现突出了室内VOC对儿科呼吸系统健康的潜在风险.
- 需要进一步的研究来阐明机制,并为公共卫生干预提供信息.
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