捕获最近的Mycobacterium tuberculosis感染的结核素皮肤测试与干扰素-玛释放试验
Jesús Gutierrez1, Mary Nsereko2, LaShaunda L Malone3
1Department of Population and Quantitative Health Science, Case Western Reserve University, Cleveland, OH 44106, USA.
Tropical medicine and infectious disease
|April 26, 2024
概括
结核素皮肤检测 (TST) 转换单独可能会高估Mycobacterium结核病 (Mtb) 感染,特别是在老年人中. 干扰素马释放试验 (IGRA) 转换,特别是与同时进行的TST转换,可能表明对Mtb.有更强大的免疫反应.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 降低结核病 (TB) 发病率需要识别患有活跃疾病高风险的个体,通常是那些最近感染了Mycobacterium tuberculosis (Mtb) 的人.
- 诸如结核素皮肤测试 (TST) 和干扰素释测试 (IGRA) 等诊断工具用于检测Mtb感染.
研究的目的:
- 在家庭接触 (HHC) 研究中评估TST在描述IGRA转换器中的附加值.
- 为了确定TST转换是否提供了超过IGRA的额外诊断信息,以识别最近的Mtb感染.
主要方法:
- 未来家庭接触 (HHC) 研究在乌干达坎帕拉.
- 使用TST和IGRA诊断新的Mtb感染.
- 对只有TST,只有IGRA和双转换器的分析.
主要成果:
- 确定了13个仅用于IGRA的转换器,39个仅用于TST的转换器和24个双转换器.
- 只有TST转换器的用户年龄较大,转换与年龄较大和拥挤程度有关.
- 与单个转换器相比,双转换器显示出更高的IGRA定量值和TST定量值的更大变化.
结论:
- 单靠TST转换可能会高估Mtb感染,这可能是由于老年人中的环境菌根增加.
- 双重IGRA/TST转换可能意味着对Mtb感染的更强大的免疫反应.
- 这些发现对结核病风险分层和疫苗开发研究有影响.
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