在轻度创伤性脑损伤后的遗传变异和持续损伤:系统性审查
Chaim M Feigen1, Molly F Charney, Simone Glajchen
1Author Affiliations: Department of Neurological Surgery, Montefiore Medical Center, Bronx, New York (Mr Feigen); Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York (Drs Charney and Lipton and Ms Glajchen); D. Samuel Gottesman Library, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York (Ms Glassman); Departments of Radiology, Psychiatry and Behavioral Sciences, and Neurology (Dr Lipton) and Dominick P. Purpura Department of Neuroscience (Mr Feigen and Dr Lipton), Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York; Tulane University, New Orleans, Louisiana (Mr Myers); New York Medical College, Valhalla, New York (Mr Cherny); New York University College of Dentistry, New York, New York (Ms Lipnitsky); and University of South Florida Health Morsani College of Medicine, Tampa, Florida (Ms Yang).
像APOE ɛ4这样的基因变异与轻度创伤性脑损伤 (mTBI) 后的持续症状有关. 需要更多的研究来了解其他影响长期mTBI恢复的遗传因素.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 创伤学 创伤学 创伤学
背景情况:
- 轻度创伤性脑损伤 (mTBI) 可以导致持续的症状和认知功能障碍.
- 识别影响mTBI结果的遗传因素对于理解长期康复至关重要.
- 遗传变异可能会改变个人在mTBI后长期损伤的风险.
研究的目的:
- 系统地审查在mTBI后与持续症状或功能障碍相关的遗传变异的初级研究.
- 评估将特定遗传变异与mTBI后30天或更长时间的结果联系在一起的证据.
- 为了确定与mTBI恢复的一致的遗传关联.
主要方法:
- 在PubMed和Embase的系统文献搜索到2022年6月.
- 包括42项检查遗传变异和mTBI结果的研究.
- 使用纽卡斯尔-太华尺度 (NOS) 进行偏差风险评估.
主要成果:
- 阿波利波蛋白E (APOE) ɛ4是与更糟糕的结果 (15/22项研究) 相关的最一致的变体.
- 在4/8项研究中,来自大脑的神经营养因子 (BDNF) Val66Met等位基因与较差的结果有关.
- 研究了12种额外的变异,其中8种显示与较差的mTBI结果相关.
结论:
- APOE ɛ4与持续的mTBI后损伤严重相关.
- 对于其他遗传变异存在有限的一致发现.
- 需要进行更大规模的,具有标准化结果的前性研究,以探索对mTBI恢复的其他遗传影响.
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