抗CD20疗法的牙科不良影响
Hélène Bartak1, Tasnim Fareh1, Nouha Ben Othman1
1Department of Pharmacology and Pharmacovigilance Center of Nice, University Hospital of Nice, Nice, France.
像ocrelizumab和rituximab这样的抗CD20疗法与严重的牙科疾病有关,包括牙衰退和牙. 接受这些治疗的患者需要积极的牙科护理和定期检查,以减轻口腔健康风险.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
- 药物监督 药物监督 药物监督
背景情况:
- 抗CD20疗法 (rituximab,ocrelizumab,ofatumumab) 越来越多地用于神经系统自身免疫性疾病,如MS,NMOSD和MG.
- 虽然一般耐受性很好,但最近的报道表明,与这些治疗相关的严重牙科副作用.
- 本研究旨在描述一系列案例,并将研究结果与现有科学文献进行比较.
研究的目的:
- 描述在接受抗CD20治疗的患者中观察到的牙科疾病.
- 为了将这些牙科疾病的发病率与现有的药监数据进行比较.
- 突出潜在的安全信号,并推预防措施.
主要方法:
- 对在抗CD20治疗期间出现牙科疾病的6例患者病例的综述,报告给药监中心.
- 对抗CD20疗法和特定牙科不良影响的Vigibase®数据的不成比例分析.
- 报告病例与科学文献的比较.
主要成果:
- 六例 (平均年龄为40.5岁) 报告了牙和牙疾病,包括牙衰退 (所有ocrelizumab患者),牙脱落,,骨折,,牙周炎.
- 在MS,MG和NMOSD的患者中,治疗开始后10天至2年发生了条件.
- 维吉巴斯 (Vigibase) 分析显示,奥克雷利祖马布 (ocrelizumab),利图西马布 (rituximab),奥法图穆马布 (ofatumumab) 和牙科病理,特别是牙和感染之间存在显著的关联.
结论:
- 这一系列病例是首次报告长期抗CD20治疗的患者的牙疾病.
- 这些发现表明一个潜在的安全信号,需要进一步调查,以更强大的研究设计.
- 积极的牙科检查和卫生措施对于接受抗CD20治疗的患者至关重要.
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