潜在的单核酸多形体标志物用于头癌患者的辐射皮肤炎:元分析
Beatriz Regina Lima Aguiar1, Elaine Barros Ferreira1,2, Ana Gabriela Costa Normando3
1Health Science Graduate Program, School of Health Sciences, University of Brasilia, Brasília, DF, Brazil.
概括
像XRCC3,TGFβ1和RAD51这样的常见遗传标记可以预测头癌患者的急性辐射皮肤炎风险. 在治疗前分析这些单核酸多态 (SNP) 可以个性化放射治疗.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 辐射疗法 辐射疗法
背景情况:
- 急性辐射皮炎 (RD) 是用于头癌的放射治疗的常见副作用.
- 识别患有严重RD风险较高的患者对于个性化治疗策略至关重要.
- 遗传因素,特别是单核酸多形态 (SNP),正在被调查为潜在的RD易感性的预测因素.
研究的目的:
- 确定与头癌患者急性辐射皮炎 (RD) 易感相关的单核酸多态 (SNP).
- 评估已识别的SNP与RD严重程度之间的关联.
- 为了解辐射引起的皮肤毒性的遗传倾向提供见解.
主要方法:
- 按照PRISMA指南进行的系统审查.
- 用于根据地理区域和RD严重程度确定遗传标记的流行率的比例元分析.
- 进行了元分析,以评估遗传标记和RD严重程度之间的关联.
- 使用GRADE标准评估的证据确定性.
主要成果:
- 综述中包括了13项研究.
- 发现的最常见的SNP是XRCC3 (rs861639) (36%),TGFβ1 (rs1800469) (35%) 和RAD51 (rs1801321) (34%).
- 在欧洲和亚洲,SNP的患病率相似 (29-40%).
- 在患有RD的患者中观察到较高的SNP患病率 (75-76%).
- 没有SNP证明了与RD严重程度的统计学上显著的关联,证据的确定性非常低.
结论:
- 普遍存在的SNP,包括XRCC3,TGFβ1和RAD51,可能作为急性RD的预测因素.
- 预处理SNP分析可以提供一个有前途的方法来预测RD风险.
- 针对放射敏感患者,可以制定个性化治疗策略.
- 本次审查强调了辐射瘤学和遗传易感性研究的新途径.
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