单剂量手术内甲用于儿童带切除术的疼痛管理:一项随机双盲临床试验
Lisa M Einhorn1, Julia Hoang2, Jong Ok La3
1Department of Anesthesiology, Pediatric Division, Duke University School of Medicine, Durham, North Carolina.
Anesthesiology
|April 26, 2024
概括
与芬太尼相比,在接受桃体切除手术的儿童中,手术内甲减少了术后阿片类药物的使用. 这项研究表明,甲是儿童桃体切除术疼痛管理的有效阿片类药物缓解剂.
科学领域:
- 麻醉学 麻醉学
- 儿科手术 儿科手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 儿科桃体切除术是一种常见的手术,具有显著的术后疼痛.
- 目前的疼痛管理策略缺乏共识,往往不充分治疗疼痛.
- 与短效阿片类药物 (如芬太尼) 相比,甲的作用持续时间更长.
研究的目的:
- 评估手术内甲在减少经过桃体切除术的儿童手术后阿片类药物消耗方面的疗效.
- 为了比较甲与芬太尼在儿科桃体切除术疼痛中的阿片类药物节约作用.
主要方法:
- 一项双盲随机试验,涉及3至17岁的儿童接受桃体切除术.
- 单剂量静脉注射甲 (0.1或0.15毫克/公斤) 与必要时使用的芬太尼的比较.
- 通过电子调查评估7天的阿片类药物使用,疼痛评分和副作用.
主要成果:
- 与对照组相比,甲醇组的7天阿片类药物的总使用量显著降低.
- 更高的甲剂量 (0.15 mg/kg) 显示,阿片类药物使用量在统计学上显著减少.
- 两组之间没有观察到术后疼痛得分或与阿片类药物相关的严重不良事件的显著差异.
结论:
- 单剂量手术内甲,特别是0.15毫克/千克,有效降低小儿桃体切除术后的阿片类药物需求.
- 与间歇性芬太尼相比,甲在这个患者群体中表现出一种阿片类药物节约作用.
- 需要进一步的研究,以在更大的研究中证实这些发现.
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