在先进固体瘤患者的第一线Avelumab加化学疗法:Ib/II期JAVELIN化学疗法医学研究的结果
Duncan A Wheatley1, Rossana Berardi2, Miguel A Climent Duran3
1Royal Cornwall Hospital, Treliske, Truro, United Kingdom.
Cancer research communications
|April 26, 2024
概括
第一线阿维卢马布加化学疗法在晚期泌尿腺癌和非小细胞肺癌 (NSCLC) 中显示出有希望的客观反应率. 尽管结论受到患者数量较少的限制,但安全性概况在阿维卢马布剂量上是一致的.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 临床试验 临床试验
背景情况:
- 化疗可以通过免疫原始化增强免疫检查点抑制剂活性.
- 研究新的组合疗法对于改善晚期癌症的治疗结果至关重要.
研究的目的:
- 评估一线阿维卢马布与化学疗法的安全性和有效性,用于晚期泌尿腺癌和非小细胞肺癌 (NSCLC) 的治疗.
- 在Ib/II期临床试验中评估剂量限制性毒性 (DLT) 和客观反应率 (ORR).
主要方法:
- 一个Ib/II期试验 (JAVELIN化学疗法Medley) 每隔3周服用阿维卢马布 (800或1200毫克) 与西斯普拉丁 + 凝丁 (心血管癌) 或碳普拉丁 + 佩姆雷克斯德 (NSCLC).
- 双重主要终点包括DLT在Ib期和确认ORR在Ib/II期.
主要成果:
- 在NSCLC队列中没有观察到DLT. 在尿路癌中,DLT发生在8.3% (800毫克) 和16.7% (1,200毫克) 的可评估患者中.
- 在尿路癌中,客观应答率为53.8% (800毫克) 和39.0% (1,200毫克),在NSCLC中为50.0% (800毫克) 和33.3% (1,200毫克).
- 艾维卢马布剂量的安全性概况相似,有效性发现与先前的研究一致.
结论:
- 第一线阿维卢马布加化学疗法在晚期泌尿腺癌和NSCLC中显示了初步的疗效和可管理的安全性.
- 需要对更大的患者队伍进行进一步的研究,以确认临床活性并优化治疗策略.
更多相关视频
06:15Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
27.4K
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
11.5K
相关概念视频
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Cancer Vaccines
359
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
359
Tumor Immunotherapy
520
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
520
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
272
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
Phenothiazines, such as prochlorperazine...
272
