卵巢癌和瘤微环境在新辅助化疗下演变的空间分析
Elisa Yaniz-Galende1, Qinghe Zeng2, Juan F Bejar-Grau1,3
1Université Paris-Saclay, Gustave-Roussy Cancer Campus, Inserm U981, Villejuif, France.
概括
新辅助化疗 (NACT) 改变卵巢癌免疫微环境,增加CD8+ T细胞并改善结果. 针对TIM3,LAG3和IDO1等免疫检查点可能会在这种恶性瘤中增强抗瘤免疫力.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症研究 癌症研究
背景情况:
- 免疫瘤微环境 (iTME) 在卵巢癌的进展和对治疗的反应中起着关键作用.
- 了解免疫细胞群中的变化及其相互作用对于开发有效的治疗策略至关重要.
研究的目的:
- 在新辅助化疗 (NACT) 之前和之后,调查卵巢癌患者的CD8+ T细胞,CD8+/Foxp3比率,HLA I表达和免疫核心调节器密度的变化.
- 为了将这些免疫变化与临床结果和患者分层相关联.
主要方法:
- 在CHIVA试验 (NCT01583322) 的对卵巢癌样本上进行了多重复合免疫分析和细胞聚类分析.
- 免疫细胞子集和免疫辅调器在NACT前后的量化.
- 基于免疫细胞组成的瘤分层的聚类分析.
主要成果:
- 诊断时较高的CD8+T细胞和HLA I表达与更好的结果相关.
- NACT显著增加了CD8+/Foxp3+比率,表明加强了免疫监测.
- 在NACT后确定的瘤群,特别是具有多样化的免疫细胞的"高BinfTinf"群,与更好的生存率有关.
- 与PDL1相比,TIM3,LAG3和IDO1的发病率更高,这表明了其他免疫检查点的目标.
结论:
- 卵巢癌表现出不同的免疫瘤微环境,这些微环境受到NACT的异质影响.
- 免疫细胞子集分析可以指导个性化治疗方法.
- 针对TIM3,LAG3和IDO1等免疫检查点可能是克服卵巢癌中抗PDL1疗法耐药性的有希望的策略.
更多相关视频
10:27Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
7.2K
07:59Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1
Published on: December 5, 2020
2.6K
相关概念视频
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...