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在儿童和青少年中非标签的Risperidone治疗的长期有效性:一个随机的,安慰剂控制的中止研究
Mariken Dinnissen1,2,3, Andrea Dietrich1,2,3, Margreet Bierens4
1Department of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Journal of child and adolescent psychopharmacology
|April 26, 2024
概括
年轻人停止服用瑞斯佩里时,表现出混合的行为结果,但显著的身体健康改善. 虽然有些人经历了复发,但许多人成功地停止了药物治疗,这凸显了需要个性化停药尝试的必要性.
科学领域:
- 儿童和青少年精神病学
- 药理学 药理学是指药理学的学科.
- 行为科学 行为科学
背景情况:
- 里斯佩里经常被处方为儿童和青少年的破坏性行为.
- 停止服用瑞斯佩里的长期益处和身体健康影响需要进一步调查.
研究的目的:
- 评估至少经过一年的治疗后,瑞斯佩里的持续益处.
- 为了评估断药对年轻人的身体健康参数的影响.
主要方法:
- 这是一项双盲研究,涉及35名年轻人 (年龄在6-18岁,智商>70) 接受了一年多的RISPERIDONE治疗.
- 参与者被随机分配到持续服用瑞斯佩里 (16周) 或停止服用 (逐渐减少2周,服用安慰剂8周).
- 结果包括破坏性行为得分,全球改善评级,侵略性尺度以及各种健康和副作用措施.
主要成果:
- 停药并没有显著改变家长报告的整体破坏性行为,但导致口头攻击和行为功能恶化.
- 在停止治疗后,体重,BMI,腰围,葡萄糖,胰岛素和益生菌水平的显著改善.
- 虽然56%的患者复发了,但44%的患者成功地停止了RISPERIDONE,这表明有些人可能会停止服用药物.
结论:
- 年轻人停止服用瑞斯佩里可能会导致身体健康的改善,但也可能与一些行为恶化有关.
- 在儿童患者中,个人尝试取消RISPERIDONE对于预防伤害和促进整体健康至关重要.
- 需要进一步的研究来确定成功停药的预测因素,并管理潜在的行为复发.
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