对风险因素与间隔和查检测乳腺癌相关性的比较分析:英国的一项大型前性研究
Isobel Barnes1, Montserrat Garcia-Closas2, Toral Gathani1,3
1Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
International journal of cancer
|April 26, 2024
概括
像BMI和家族史这样的乳腺癌风险因素在与间隔与查检测癌症的关联上有所不同. 这些差异可能反映出风险因素如何影响乳房检查密度和查灵敏度.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 放射学 放射学是一门学科.
背景情况:
- 已确定的乳腺癌风险因素,如年龄和更年期激素治疗,与间隔和查检测的癌症有不同的关联.
- 其他常见的乳腺癌风险因素对癌症检测模式的差异性影响仍然在很大程度上未被描述.
研究的目的:
- 研究一系列已确定的乳腺癌风险因素是如何与间隔和查检测乳腺癌相关的.
- 为了确定风险因素与乳腺癌风险之间的关联强度是否因检测方法 (查与间隔) 而异.
主要方法:
- 利用来自英国大型队列的数据,与国家卫生服务乳腺查计划,癌症登记册和健康记录相关联.
- 采用考克斯回归分析来计算调整的相对风险 (RR) 和风险因子关联的95%置信区间 (CI).
- 分析了517,555名妇女的数据,在平均随访时间9.72年内确定了9421例查检测和5166例间隔乳腺癌.
主要成果:
- 较高的体重指数 (BMI) 与查检测癌症 (RR 1.27) 相比,与间隔癌症风险增加的关联较弱 (RR 1.07).
- 一级家族病史与间歇性癌症 (RR 1.81) 的风险增加比查检测癌症 (RR 1.52) 的风险增加更为强烈.
- 之前的乳腺外科手术与间隔癌症风险增加的相关性更强 (RR 1.85) 与查检测癌症相比 (RR 1.34).
结论:
- 在BMI,家族病史和之前的乳腺手术与间隔与查检测的乳腺癌的关联中存在显著差异.
- 这些观察到的差异很可能归因于这些风险因素对乳腺扫描密度的影响,因此对查敏感度的影响.
- 研究结果表明,风险因素和乳房扫描密度之间的相互作用会通过查计划影响癌症的检测能力.
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