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Updated: Jun 27, 2025

Mapping Mammalian 3D Genome Interactions with Micro-C-XL
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通过基因-表观遗传相互作用建模在小鼠中的3D基因组结构的推算

Lauren Kuffler1, Daniel A Skelly1, Anne Czechanski1

  • 1The Jackson Laboratory, Bar Harbor, United States.

eLife
|April 26, 2024
PubMed
概括

遗传和表观遗传因素在三维 (3D) 染色质结构中相互作用,影响基因表达. 这项研究揭示了这些相互作用是全基因组普遍的,并受到3D基因组架构的约束,而不仅仅是线性DNA序列.

关键词:
染色质可访问性 染色质可访问性计算生物学是计算生物学.胚胎干细胞是一种胚胎干细胞.基因相互作用 基因相互作用遗传学 遗传学 遗传学 是一个基因组学就是基因组学.这里是鼠标鼠标鼠标鼠标鼠标鼠标.系统生物学 系统生物学在拓上关联域名.

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