空气颗粒污染和怀孕期间高血压疾病之间的关联:一个回顾性队列研究
Yi Sun1,2, Rashmi Bhuyan2,3,4, Anqi Jiao2
1Institute of Medical Information, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
PLoS medicine
|April 26, 2024
概括
暴露于细颗粒物 (PM2.5) 增加了怀孕期间产前和产后 (PE-E) 的风险,特别是在西班牙裔和非裔美国母亲身上. 具体的PM2.5成分和怀孕期间暴露时间显著影响PE-E风险.
科学领域:
- 环境健康 环境健康
- 产科和妇科 产科和妇科
- 流行病学 流行病学
背景情况:
- 关于微粒≤2.5μm (PM2.5) 和妊娠高血压疾病 (HDP) 的流行病学数据不一致.
- 关于特定的PM2.5成分,混合物效应和临界暴露窗口对HDP风险的影响的证据有限.
研究的目的:
- 调查怀孕期间暴露于PM2.5及其成分与HDP风险之间的关联.
- 为了确定敏感的暴露窗口和对妊娠高血压 (GH) 和子宫前/子宫 (PE-E) 的差异性影响.
主要方法:
- 在南加利福尼亚州 (2008-2017) 进行了386,361例怀孕的回顾性队列研究.
- 使用精细分辨率模型估计的PM2.5总质量和成分 (硫酸盐,酸盐,,有机物质,黑碳).
- 采用了多级Cox比例危险模型,量子g计算和分布式滞后模型.
主要成果:
- 对PE-E (而不是GH) 的相对风险增加与PM2.5总质量,黑碳和有机物质暴露有关.
- 根据EPA标准,与PM2.5相关的PE-E人口可归因分数为6.37%.
- 黑碳是PM2.5混合物效应的最大贡献者;易受影响的窗口是第一和第二季度晚期.
- 在西班牙裔,非裔美国人和低收入到中等收入的母亲中观察到更高的风险.
结论:
- 暴露于PM2.5,其组成部分,混合效应和特定暴露窗口与PE-E风险相关.
- 调查结果强调PM2.5对GH和PE-E的不同影响,对孕产妇健康差异有重大影响.
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