固体器官移植后骨损失和骨折的药理预防:系统审查和网络元分析的议定书
Jiawen Deng1,2,3, Myron Moskalyk4, Wenteng Hou1,5
1Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
PloS one
|April 26, 2024
概括
固体器官移植接受者因医疗条件和治疗而面临骨损失和骨折. 该网络的元分析对抗骨质疏松症疗法进行了排名,以指导骨矿物质密度和骨折减少的有效管理.
科学领域:
- 移植医学 移植医学
- 骨的新陈代谢 骨的新陈代谢
- 药理学 药理学是指药理学的学科.
背景情况:
- 固体器官移植 (SOT) 接受者容易发生骨损失,骨矿物质密度 (BMD) 降低,骨折风险增加.
- 潜在的疾病和免疫抑制药物对SOT患者的骨脆弱性有显著的贡献.
研究的目的:
- 对随机对照试验 (RCT) 进行全面的网络元分析 (NMA).
- 根据其在减少骨折和增加SOT接受者的BMD方面的有效性,对抗骨质疏松症的干预措施进行排名.
主要方法:
- 在多个数据库 (MEDLINE,EMBASE,Web of Science,CINAHL,CENTRAL,CNKI) 中系统地搜索相关的RCT.
- 重复查和数据提取,分析骨质量变化 (平均差异) 和骨折发生率 (风险比率).
- 采用积累性排名下的表面 (SUCRA) 评分进行干预排名,并使用RoB2/CINeMA进行质量评估.
主要成果:
- 国家管理局将提供所有可用的RCT数据的定量综合.
- 干预措施将根据其改善骨质量和降低骨折风险的有效性进行排名.
- 这项研究将提供各种抗骨质疏松症药物疗法的强有力的比较.
结论:
- 这一系统性审查和NMA代表了对SOT接受者的骨损失管理的最广泛的定量分析.
- 结果将为药物治疗的临床建议提供信息,以减轻移植后的骨损失和骨折.
- 结果将通过同行评审的出版物传播,以帮助临床医生和患者.
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