定义初级耐火性大B细胞淋巴瘤的定义
Allison M Bock1,2, Raphael Mwangi3, Yucai Wang1
1Division of Hematology, Mayo Clinic, Rochester, MN.
Blood advances
|April 26, 2024
概括
定义初级耐火性大B细胞淋巴瘤 (LBCL) 是至关重要的. 在前线治疗期间患有进展性疾病 (PD) 的患者的生存率明显降低,这表明对初级耐火性LBCL的定义有所改进.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 大型B细胞淋巴瘤 (LBCL) 患者在免疫化学疗法 (IC) 后未达到完全反应或早期复发后,预后不佳.
- 目前对初级耐火性疾病的定义各不相同,影响临床实践和研究.
研究的目的:
- 根据复发时间来定义耐火状态的变化.
- 评估一次性耐火性LBCL的不同定义与生存结果之间的关联.
主要方法:
- 分析了两个独立的队列:分子流行病学资源 (MER; N=949) 和淋巴瘤流行病学结果 (LEO; N=2755).
- 在2002年9月至2021年5月期间被诊断出新诊断的LBCL的LBCL患者.
- 主要耐火性LBCL是由初级进展性疾病 (PPD),部分反应 (PR) 或早期复发 (CR后3-12个月) 定义的.
主要成果:
- 与部分反应或早期复发患者相比,患有初级进展性疾病 (PPD) 的患者的整体存活率 (OS) 显著下降.
- 在MER队列中,PPD的2年OS率为15%,PR为38%,早期复发为44%.
- 在LEO队列中,PPD的2年OS率为31%,PR为50%,早期复发为58%.
结论:
- 在前线IC期间经历稳定疾病 (SD) 或进展性疾病 (PD) 的患者代表了具有糟糕结果的独特子组.
- 建议对初级耐火性LBCL进行细化定义,即在前线治疗期间或结束时将SD或PD定义为SD或PD.
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