单细胞与高密度脂蛋白比率与高尿素血的关联:从2009年到2018年的结果
Lei Cao1, Chunwei Wu2, Miao Liu1
1College of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China.
Medicine
|April 26, 2024
概括
单细胞与高密度脂蛋白 (MHR) 的比率与美国人口的高尿素血风险有积极的相关性. 这种炎症生物标志物显示出女性高尿路血的更强的预测价值.
科学领域:
- 心血管和代谢疾病 心血管和代谢疾病
- 生物标志物和诊断方法
- 公共卫生研究 公共卫生研究
背景情况:
- 单细胞高密度脂蛋白比率 (MHR) 是一个新兴的炎症生物标志物,有可能预测心血管和代谢疾病.
- 之前对MHR和高尿血的研究受到小样本大小的限制,需要进行更大规模的调查.
研究的目的:
- 通过使用大型,具有全国代表性的数据集,调查MHR和高尿血症之间的关联.
- 探索MHR对高尿血的预测能力,包括子组分析和非线性关系.
主要方法:
- 这是一项采用2009-2018年国家健康和营养检查调查 (NHANES) 数据的横截面研究.
- 包括17694名具有完整数据的参与者;MHR是根据单细胞计数和高密度脂蛋白水平计算的.
- 统计分析包括加权多变量逻辑回归,子组分析,平滑曲线拟合和值分析.
主要成果:
- 在MHR和高尿血症之间发现了显著的正相关性 (P < .001,OR = 1.98).
- 超尿血症组的MHR水平较高,与BMI升高有关.
- 对于高尿血的MHR的预测值在女性中更为明显,具有非线性关联和0.826.8的拐点.
结论:
- 在美国,MHR与美国成年人群中高尿路血的患病率有积极的关联.
- MHR 作为高尿血症风险的有价值预测指标,特别是在女性中.
- 需要进一步的研究来验证这些发现并阐明潜在的机制.
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