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雌激醇和口腔之间的因果关系:孟德尔的随机化研究

Yaqian Zhang¹, Kunting Zhong, Weiyu Liang

¹Research Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.

|April 26, 2024

概括

这项研究没有发现雌醇水平与男性或女性口腔之间的因果关系. 需要进一步的研究来确认雌醇是否可以用于治疗口腔.

科学领域:

遗传学是一个遗传学.
内分泌学在内分泌学.
口腔医学是指口腔医学.

背景情况:

口腔会引起严重的不适,影响饮食和说话.
雌激素在口腔的发展和治疗中的作用受到争议,研究结果相互矛盾.
澄清雌激醇与口腔之间的关系对于潜在的治疗策略至关重要.

研究的目的:

使用孟德尔随机化研究雌激醇和口腔之间的潜在因果关系.
评估男性和女性雌醇水平对口腔的发生率的影响.
通过控制潜在的混因素来评估协会的稳定性.

主要方法:

使用了2个样本的门德尔随机化 (MR) 和多变量门德尔随机化 (MVMR) 分析.
采用来自IEU OpenGWAS项目和英国生物库的大规模遗传数据,用于雌醇和口腔的数据集.
采用了各种MR方法 (MR-Egger,加权中位数,IVW) 和灵敏度分析 (Cochran Q,MR-Egger拦截,MR-PRESSO,留出一个).

主要成果:

在男性雌激素水平和口腔之间没有发现统计学上显著的因果关系 (IVW P=0.18).
在女性雌激素水平和口腔之间没有发现统计学上显著的因果关系 (IVW P=0.97).
MVMR分析证实男性雌激素和口腔之间没有因果关系,而女性的关联由于有限的SNP而没有确定性.

结论:

目前的证据不支持雌醇和口腔之间的因果关系,无论男女.
雌醇在口腔的潜在治疗用途需要在更广泛的研究中进行进一步的研究和验证.
门德尔随机化分析表明,雌激醇不太可能是口腔的直接因果因素.

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