运动对尿道AD7c-NTP (与阿尔茨海默症相关的神经线程蛋白) 水平和认知功能在活跃的韩国老年人中的影响:一项随机对照试验
Donghyun Kim1, Parivash Jamrasi1, Xinxing Li1
1Department of Physical Education, Health and Exercise Science Laboratory, Seoul National University, Seoul, Republic of Korea.
Journal of Alzheimer's disease : JAD
|April 26, 2024
概括
运动干预显著降低了与阿尔茨海默氏症相关的神经线蛋白 (AD7c-NTP) 在活跃的韩国老年人尿液中的水平. 较低的AD7c-NTP与改善的认知功能和握力相关.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 生物化学 生物化学
背景情况:
- 与阿尔茨海默病相关的神经线程蛋白 (AD7c-NTP) 是阿尔茨海默病 (AD) 的生物标志物.
- 在老年人群中,运动对尿道AD7c-NTP水平的影响仍未得到充分研究.
- 了解运动对AD生物标志物的影响,对于预防策略至关重要.
研究的目的:
- 为了确定12周的运动干预对尿道AD7c-NTP水平的影响.
- 评估运动对韩国活跃老年人的认知功能和体力的影响.
- 探索AD7c-NTP水平,认知得分和握力之间的相关性.
主要方法:
- 40名韩国老年参与者 (≥65岁) 被分配到对照,有氧运动或联合阻力/有氧运动组.
- 一项为期12周的干预包括认知测试 (K-MMSE,Stroop),握力,身体组成和尿道AD7c-NTP测量 (ELISA).
- 尿样和身体/认知评估在基线和干预后收集.
主要成果:
- 与对照组相比,有氧运动和综合运动组都显示尿液AD7c-NTP水平显著降低.
- 尿液中的AD7c-NTP水平与韩国迷你精神状态考试 (K-MMSE) 成绩有显著的负相关性.
- 在尿液中的AD7c-NTP水平和握力之间也观察到显著的负相关性.
结论:
- 这项研究提供了第一个证据表明,运动干预可以降低活跃的老年人尿道AD7c-NTP水平.
- 运动可能在缓解AD病理方面发挥作用,如AD7c-NTP降低所示.
- 未来的研究应该专注于认知功能和活动水平较低的个体,以进一步阐明运动的影响.
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