高龄与更好的无进展生存的相关性,尽管在非功能性垂体腺瘤中进行了不那么积极的切除
Yuki Shinya1,2, John L D Atkinson1, Dana Erickson3
1Departments of1Neurologic Surgery and.
Journal of neurosurgery
|April 26, 2024
概括
患有非功能性垂体腺瘤 (NFPAs) 的老年患者经历了经过内外科手术 (ETS) 后更长的无进展生存期 (PFS). 然而,较年轻的年龄与男性阴性双胞胎症的改善结果有关.
科学领域:
- 神经外科 神经外科
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
背景情况:
- 非功能性垂体腺瘤 (NFPAs) 是常见的瘤,患者在呈现时年龄可变.
- 患者的年龄可能会影响手术治疗后的长期结果.
- 脑膜外科手术 (ETS) 是NFPAs的主要治疗方式.
研究的目的:
- 调查ETS后NFPA患者的长期结果.
- 探索患者在报告时的年龄对结果的影响,包括无进展生存率 (PFS) 和神经/内分泌结果.
- 为了进行比较分析,将患者分为各个年龄组进行分层.
主要方法:
- 对228名经过ETS的NFPA患者进行了回顾性研究.
- 随访时间中位数为63个月.
- 年龄分层分为四组 (≤49,50-59,60-69,≥70岁),使用卡普兰-梅尔和考克斯的比例危险分析.
主要成果:
- 年龄较大与较长的PFS显著相关 (PFS5年率在63.0%至88.1%之间,p=0.001).
- 多变量分析证实较长的年龄 (HR 1.03),较小的瘤直径 (HR 0.77),和总体切除 (HR 8.55) 作为更长的PFS的预测因素.
- 较年轻的年龄是男性阴性双胞胎症术后改善的唯一因素 (HR 0.91);其他内分泌和神经学的结果并不取决于年龄.
结论:
- 接受ETS治疗的NFPA患者中的老年患者表现出明显更长的PFS.
- 在年轻的患者中,男性阴高性腺症的术后改善更有可能发生.
- 年龄是影响PFS的关键因素,但并非所有内分泌/神经结果都在NFPAs的ETS之后发生.
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