丁酸盐抑制了eosinophilic慢性鼻炎的2型炎症
Masatomo Toyama1, Hideaki Kouzaki2, Takeshi Shimizu2
1Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, 903-0215, Japan; Department of Otorhinolaryngology and Head and Neck Surgery, Shiga University of Medical Science, Otsu, Shiga, 520-2192, Japan.
Biochemical and biophysical research communications
|April 26, 2024
概括
短链脂肪酸 (SCFA) 酸通过抑制细胞因子和IgE生产来抑制2型炎症. 低酸盐水平在异性慢性鼻炎 (ECRS) 中表明其治疗潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 短链脂肪酸 (SCFA),微生物代谢物,与抑制2型炎症有关.
- 鼻腔内SCFA的精确机制,特别是在eosinophilic慢性鼻炎 (ECRS) 中,仍然不完全理解.
研究的目的:
- 阐明SCFA在ECRS病理生理学中的体外和体内作用.
- 研究SCFA对2型细胞因子,免疫球蛋白E (IgE) 和亡的作用.
- 探索G蛋白结合受体41 (GPR41),43 (GPR43) 和基因素脱乙酶 (HDAC) 在SCFA介导作用中的参与.
主要方法:
- 在体外分析SCFA对外周血液单核细胞 (PBMC),2型先天性淋巴细胞 (ILC2s),CD4+T细胞和CD19+B细胞的影响.
- 在ECRS患者和对照组的鼻洗液中SCFA度的体内评估.
- 亡测定 (附件V) 和对GPR41,GPR43和HDAC通路的调查.
主要成果:
- 丁酸盐显著抑制了PBMCs,ILC2s和CD4+T细胞中的2型细胞因子产生,以及B细胞中的IgE产生.
- 丁酸盐在PBMC中诱导了晚期亡.
- HDAC抑制,但不是GPR41或GPR43信号,与丁酸盐的抗炎作用有关.
- 丁酸盐在ECRS患者衍生的PBMC和鼻细胞中对2型细胞因子产生有抑制作用.
- 与对照人群相比,ECRS患者的鼻洗液中发现酸盐度明显较低.
结论:
- 丁酸盐有效抑制2型炎症,表明在ECRS中具有潜在的治疗作用.
- 在ECRS患者中降低的丁酸盐水平突显了其作为生物标志物和治疗点的潜力.
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