在癌症中劫持了增强器-促进器和消声器-促进器循环
1Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, China; Shanghai Key Laboratory of Reproduction and Development, Shanghai, China.
Current opinion in genetics & development
|April 26, 2024
概括
结构变异 (SVs) 破坏癌症的3D基因组组织,改变基因表达并促进瘤发生. 本综述探讨了SVs对基因组结构,基因调节和癌症临床影响的影响.
科学领域:
- 基因组学就是基因组学.
- 癌症生物学 癌症生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 结构变异 (SVs) 越来越多地被认为在癌症中的作用超出了融合基因的形成.
- SVs可以深刻改变三维 (3D) 基因组组织,影响基因表达和瘤发生.
- 了解这些高阶结构变化对于癌症研究至关重要.
研究的目的:
- 审查结构变异 (SVs) 如何破坏癌症中的3D基因组组织.
- 讨论SVs调节基因表达失调并导致瘤发生的机制.
- 突出研究癌症中SV和基因组结构的临床影响和未来挑战.
主要方法:
- 关于癌症中的结构变异和基因组组织的最新研究的文献综述.
- 分析涉及染色体循环,拓关联域 (TAD) 和分区的机制.
- 讨论由SVs.介导的瘤基因激活和瘤抑制基因抑制.
主要成果:
- SVs可以通过通过染色质循环重新安置它们来改变增强器/沉默器活性.
- 在癌症中观察到TADs (扩张,混合,新TADs) 和隔间开关的变化.
- 通过破坏3D基因组架构来调节基因表达失调,SVs有助于瘤发生.
结论:
- 通过改变3D基因组结构和基因表达,SVs在癌症发育中发挥着重要作用.
- 针对SV介导的基因组破坏具有癌症治疗的潜力.
- 需要进一步的研究,以充分阐明SVs,基因组组织和癌症进展之间的复杂相互作用.
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