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在帕金森病的亚thalamic核深度大脑刺激手术后延迟发作

Bin Wu¹, Jinlong Liu², Lulu Jiang³

¹Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China; Department of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

|April 26, 2024

概括

在帕金森病下进行下丘脑核深脑刺激 (STN-DBS) 后出现的延迟发作是罕见的 (1.47%) 和短暂的. 较大的环电极胀是这些发作的重要危险因素.

科学领域:

神经外科神经外科
神经学神经学
医疗技术医疗技术医学技术

背景情况:

经过深度脑刺激 (DBS) 手术后的延迟发作的发作很少被记录在案.
这项研究调查了帕金森病 (PD) 延迟发作后亚体核 (STN) DBS的临床特征和危险因素.

研究的目的:

总结STN-DBS后在PD患者中延迟发作的临床特征.
为了确定与这些术后发作相关的危险因素.

主要方法:

一个单一中心连续STN-DBSPD患者 (2006-2021) 的回顾性分析.
在手术期间或手术后一个月内发生的发作的识别.
对术后MRI扫描和统计方法进行分析,以确定风险因素.

主要成果:

在341名PD患者中,有5名患者 (1.47%的发病率) 经历了延迟发作的发作,平均在手术后12天.
所有的发作都是通用性强力-克隆性和自我限制的;在两个半球中观察到围电极.
患有的患者有显著更大的围电极胀 (3.15厘米对比1.57厘米;p=0.005).

结论:

晚发性发作后的STN-DBS对于PD是不常见的,通常是短暂的,不会导致慢性.
周电极是延迟发作发作的重要危险因素.
平均周电极的直径大于2.70厘米会增加发作风险.

关键词:

深度大脑刺激 (DBS) 的方法延迟发作的发作帕金森病 (PD) 是一种疾病.周电极胀周电极胀亚体体内核 (STN) 亚体内核

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