在炎症期间IL-23调节髓状细胞生物学
Kevin M-C Lee1, Tanya Lupancu1, Leon Chang2
1Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria 3050, Australia.
Cytokine
|April 26, 2024
概括
干白素-23 (IL-23) 对于巨细胞激活和促炎性细胞因子的产生至关重要,特别是颗粒细胞群刺激因子 (G-CSF). 这项研究表明,IL-23在炎症条件下调节中性粒细胞数量.
科学领域:
- 免疫学 免疫学 免疫学
- 具有天生的免疫力.
- 炎症生物学 炎症生物学
背景情况:
- 干白素-23 (IL-23) 主要与炎症性疾病中的T辅助体17 (Th17) 细胞反应有关.
- 新出现的证据表明IL-23在炎症期间的先天性免疫细胞功能中发挥了作用.
研究的目的:
- 研究内源性IL-23在巨细胞激活和先天免疫反应中的作用.
- 为了确定IL-23p19遗传删除和中和对腹膜炎模型的影响.
主要方法:
- 在实验室中使用齐莫桑刺激对巨细胞激活的评估.
- 在IL-23p19缺乏和IL-23中和的小鼠中对齐莫桑诱导腹膜炎 (ZIP) 模型的评估.
- 测量促炎性细胞因子,包括G-CSF,以及排泄液中的中性粒细胞计数.
主要成果:
- 内源IL-23对于齐莫桑最大限度地激活巨细胞至关重要,可显著上调诸如G-CSF.等促炎性细胞因子.
- 在ZIP模型中IL-23p19遗传删除或中和减少了中性粒细胞数量和排泄液中的G-CSF水平.
- IL-23直接上调巨细胞G-CSF的表达,可能是通过自/副机制.
结论:
- 内源IL-23在炎症期间对巨细胞激活和G-CSF表达起着重要作用.
- IL-23有助于调节中性粒细胞数量和在炎症反应中的功能.
- 向IL-23可能对具有中性粒细胞参与的炎症性疾病有益.
相关概念视频
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
Differentiation of Common Myeloid Progenitor Cells
3.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.2K
Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
Inflammatory Response
2.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.0K
Lineage Commitment
3.0K
Commitment is the process whereby stem cells:
3.0K


