运动,体感和执行皮层区域在听觉中脑引起单突触和多突触神经元活动
Sarah E Gartside1, Bas Mj Olthof1, Adrian Rees1
1Centre for Transformative Neuroscience and Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom.
Hearing research
|April 26, 2024
概括
皮层区域直接激发听觉中脑神经元. 这项研究表明,像运动皮质这样的非听觉大脑区域通过直接,刺激性连接到下层结合体 (ICc) 来影响声音处理.
科学领域:
- 神经科学是一个神经科学.
- 审计系统研究 审计系统研究
- 皮层连接 皮层连接 皮层连接
背景情况:
- 作为听觉中脑的一部分,下结核 (ICc) 的中心核从听觉和非听觉皮质区域接收输入.
- 了解这些下降连接的功能影响对于理解听觉处理和与其他感官模式的整合至关重要.
研究的目的:
- 为了研究从各种皮质区域到ICc.的谷氨酸基质金字塔细胞投射的功能影响.
- 确定单突触刺激的程度和对ICc.内的自发活动的影响.
主要方法:
- 在麻醉老鼠中利用光遗传学和电刺激.
- 使用逆向病毒追踪 (编码GFP和channelrhodopsin-2) 来识别和激活向ICc投射的皮质神经元.
- 在ICc中记录神经元活动,以评估对皮层刺激的反应.
主要成果:
- 听力皮层 (AC) 和初级运动皮层 (M1) 的光遗传学刺激引起了ICc的直接刺激输入,增加了神经元发射率.
- 在M1,二级运动,体感和前额皮层的电刺激引发了单突触刺激 (延迟约5毫秒) 和ICc中的多突触刺激.
- 刺激反应显示出有限的分布,表明特定的皮质-ICc连接,增加刺激电流招募更多的神经元并增强反应.
结论:
- 从运动,体感和执行皮质区域的下降连接直接激活ICc神经元的一个子集.
- 这种直接激活会导致ICc.内部局部电路的随后广泛的多突触激发.
- 这些发现强调了非听觉皮质区域在调节听觉中脑活动中的重要作用.
相关概念视频
Motor and Sensory Areas of the Cortex
3.8K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
3.8K
Auditory Pathway
5.4K
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
5.4K
Somatosensory, Motor, and Association Cortex
490
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
490
Association Areas of the Cortex
5.3K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
5.3K
Hearing
52.1K
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
52.1K
Brainstem
2.0K
The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
2.0K


