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Updated: Jul 19, 2026

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
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突变引导的疫苗设计:一种开发促进HIV免疫原的过程,广泛中和抗体诱导的免疫原

Kevin Wiehe1, Kevin O Saunders2, Victoria Stalls3

  • 1Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA; Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

Cell host & microbe
|April 26, 2024
PubMed
概括

设计有效的HIV-1疫苗是一项挑战. 这项研究开发了新型蛋白质和mRNA免疫原,成功选择了罕见的B细胞突变,推动了HIV疫苗广泛中和抗体 (bnAbs) 的开发.

关键词:
B细胞的发育过程艾滋病毒疫苗 艾滋病毒疫苗亲缘关系成熟的成熟.广泛中和抗体的抗体.不可能的突变是不可能的突变.这是mRNA疫苗.疫苗的设计是如何设计的

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