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SARS-CoV-2对肠道但不是胃上皮细胞的热带性是由有限的ACE2表达定义的

Mindaugas Paužuolis¹, Diana Fatykhova², Boris Zühlke³

¹Research Centre for Infectious Diseases, Institute for Molecular Infection Biology, Julius Maximilians Universität Würzburg, Würzburg, Germany.

Stem cell reports

|April 26, 2024

概括

严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染了肠道,但没有感染胃. ангиотензин转化酶2 (ACE2) 表达决定了胃肠道中SARS-CoV-2的易感性,影响病毒的复制和传播.

科学领域:

胃肠病学胃肠病学
病毒学病毒学
细胞生物学细胞生物学

背景情况:

严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 导致肺部和胃肠道 (GI) 症状.
虽然已知肠道上皮是受感染的,但胃上皮的易感性却不太清楚.
在主要的胃肠道段中缺乏SARS-CoV-2感染的直接比较.

研究的目的:

为了直接比较成人胃肠表皮与肠表皮的SARS-CoV-2感染易感性.
为了研究血管酶转化酶2 (ACE2) 在SARS-CoV-2胃肠道热带的作用.
为了将体外发现与患者的胃肠道组织特征相关联.

主要方法:

在体外感染研究中使用了来自有机体的单层.
进行RNA测序和蛋白质组分析以确定关键的分子因素.
在患者的胃肠道活检中检查了ACE2表达.

主要成果:

SARS-CoV-2 强烈感染肠道上皮质,但没有胃上皮质.
鉴定出ACE2是关键因素;宫外ACE2表达使胃细胞易感.
患者胃肠道活检ACE2表达模式与观察到的体外感染水平相关.

结论:

局部ACE2表达决定了肠道内的SARS-CoV-2热流,主要针对肠道.
由于ACE2表达率低,胃很可能对SARS-CoV-2感染具有抗性.
肠道在SARS-CoV-2复制和潜在的传播中发挥着重要作用.

关键词:

在ACE2中,ACE2是ACE2.这就是SARS-CoV-2病毒.胃肠道上皮质胃肠道上皮质感染模型的感染模型我们的肠道是肠道.有机生物有机物胃胃胃胃胃胃

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