老化中的大脑弹性图与流体/固体趋势线有关
Kevin J Parker1,2,3, Irteza Enan Kabir1, Marvin M Doyley1,2,3
1Department of Electrical and Computer Engineering, University of Rochester, 724 Computer Studies Building, Box 270231, Rochester, NY 14627, United States of America.
Physics in medicine and biology
|April 26, 2024
概括
大脑弹性图显示,老化导致大脑组织因水分增加和细胞外基质减少而变软. 粘弹性质的这些变化与灰色和白色物质与年龄相关的结构变化相关.
科学领域:
- 神经科学是一个神经科学.
- 生物物理学的生物物理.
- 生物医学工程 生物医学工程
背景情况:
- 大脑衰老涉及到形态和组成的变化.
- 大脑弹性图显示与年龄相关的粘弹性质的软化.
- 了解这些变化对于诊断神经系统疾病至关重要.
研究的目的:
- 确定驱动大脑粘性弹性的与年龄相关的变化的因果机制.
- 确定哪些结构因素会影响灰色和白色物质随时间变硬.
- 阐明大脑弹性图在研究衰老,疾病和损伤中的作用.
主要方法:
- 分析了老年成年人的弹性图像数据.
- 综合了先前关于大脑组成研究的综合数据.
- 利用了大脑液体/固体结构的生物物理模型.
主要成果:
- 与年龄相关的细胞外水的增加和细胞外基质的减少显著影响大脑粘性弹性.
- 灰色物质的刚度与水分的平方相反地下降.
- 白物质的刚度与水分数相反而下降到2/3的功率,反映了轴突结构.
结论:
- 大脑弹性图像对水和细胞外基质与年龄相关的变化敏感.
- 这些发现突出了弹性图像作为微观结构变化的宏观指标.
- 对衰老,神经疾病和脑损伤的临床研究的影响.
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