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Rational Dosage Regimen: Maintenance Dose and Loading Dose01:24

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A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
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Dosage Regimen: Fixed Dose01:01

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Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
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Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
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The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it...
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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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在使用多目标贝叶斯优化的高剂量速率支臂疗法中进行惩罚性权重调整.

Hossein Jafarzadeh1, Majd Antaki1, Ximeng Mao2

  • 1Medical Physics Unit, Department of Oncology, McGill University, Montreal, Quebec, Canada.

Physics in medicine and biology
|April 26, 2024
PubMed
概括

这项研究引入了多目标贝叶斯优化与q-noisy预期的超容量改善 (MOBO-qNEHVI),以自动化高剂量率支臂疗法治疗计划. 该方法有效地找到最佳计划,减少对策划者经验的依赖,改善危险器官节约.

关键词:
贝叶斯优化的贝叶斯优化快速支架MCTPSPS的使用情况高剂量率手臂疗法 (brachytherapy) 是一种高剂量率手臂疗法.混合整数优化混合整数优化优化多个标准的优化.前列腺癌是前列腺癌.

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科学领域:

  • 医学物理 医学物理
  • 辐射瘤学 辐射瘤学
  • 计算生物学 计算生物学

背景情况:

  • 高剂量速率支臂疗法治疗计划的优化通常依赖于手动调整惩罚权重,这耗时且依赖于经验.
  • 自动化这个过程对于提高治疗规划的效率和一致性至关重要.

研究的目的:

  • 使用多目标贝叶斯优化与q-noisy预期超体积改善 (MOBO-qNEHVI) 来自动化高剂量速率支架疗法治疗计划优化.
  • 研究MOBO-qNEHVI代与临床上可接受计划的速度之间的关系.
  • 评估自动化优化过程的性能时间和效率.

主要方法:

  • 使用研究治疗计划系统 (RapidBrachyMTPS) 对13名前列腺癌患者治疗计划的回顾性分析.
  • 应用MOBO-qNEHVI与快速混合整数优化 (FMIO) 来找到患者特定的帕雷托最佳惩罚权重向量.
  • 调查各种参数配置的接受率和性能时间.

主要成果:

  • MOBO-qNEHVI成功地为所有患者生成了临床上可接受的治疗计划.
  • 计划接受率在更多MOBO-qNEHVI代时以逻辑上升,而执行时间则呈指数增长.
  • 优化的参数 (6次代,25个并行FMIO样本) 实现了目标剂量与最小的器官危险剂量交付,在66.6秒内产生了89.74%的平均接受率.

结论:

  • MOBO-qNEHVI与FMIO相结合,提供了一种自动化的,针对患者的方法,在几分钟内优化支臂治疗治疗计划.
  • 这种方法减少了对策划者的专业知识的依赖,并可以将风险器官的辐射剂量降到最低.
  • 这种方法显示了改善手臂疗法治疗规划质量和效率的巨大潜力.