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血清尿酸与老年心力衰竭患者的萨尔科佩尼亚之间的关系,老年心力衰竭患者有保存的喷射分数
Miao Lu1, Yansong Li1, Yiting Pan1
1Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, Jiangsu 210029, China.
Experimental gerontology
|April 26, 2024
概括
在老年心力衰竭患者中,随着血清尿酸 (UA) 水平的升高,肉症的患病率会增加,心力衰竭患者具有保存的喷射分数 (HFpEF). 这种关联在男性中显著,因此需要进一步研究最佳的UA减少策略.
科学领域:
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 代谢研究研究 代谢研究
背景情况:
- 保存喷射分数 (HFpEF) 的心力衰竭对健康构成重大风险.
- 萨科佩尼亚是HFpEF患者常见的疾病,可使预后恶化.
- 血清尿酸 (UA) 的升高对心血管健康有害.
研究的目的:
- 为了研究老年HFpEF患者的萨尔科佩尼亚和血清UA水平之间的关系.
- 为了确定更高的UA水平是否与增加的肉症患病率有关.
- 探索这种关联中潜在的基于性别的差异.
主要方法:
- 分析了180名老年HFpEF患者的数据.
- 将血清UA值分组成四分位数进行比较.
- 使用后勤通用线性模型和受限立方线 (RCS) 回归.
- 根据性别进行子组分析.
主要成果:
- 经过调整后的分析显示,UA四分位数的增加和肉类的患病率之间存在积极的趋势 (趋势P=0.022).
- RCS回归表明血清UA和肉症之间存在正线性关系 (非线性的P=0.190).
- 在男性 (P <0.05) 中观察到UA和肉症之间的统计学意义上的关联.
结论:
- 在老年HFpEF患者中,肉症的患病率与血清UA水平有关.
- 这些发现表明,在这个人群中,UA升高和肌肉消耗之间存在潜在的联系.
- 需要进一步的纵向研究来证实这些发现,并确定最佳的UA目标.
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