开发 TSHR-CAR NK-92 细胞用于差异化甲状腺癌
Jiahui Zhou1, Chengcheng Zhang2, Weibo Mao1
1Department of Pathology, LiShui Central Hospital, The Fifth Hospital Affiliated to Wenzhou Medical University, Zhejiang Province, China.
Molecular and cellular endocrinology
|April 26, 2024
概括
针对甲状腺刺激激素受体 (TSHR) 的化学抗原受体 (CAR) 修饰的自然杀手 (NK) 细胞显示出治疗差异化甲状腺癌 (DTC) 的前景. 这些工程NK细胞有效地抑制了小鼠的DTC瘤,提供了潜在的新疗法.
科学领域:
- 免疫治疗是一种免疫疗法.
- 在瘤学瘤学.
- 细胞疗法细胞疗法
背景情况:
- 分化甲状腺癌 (DTC) 对复发,转移或耐火病例的治疗选择有限.
- 化学抗原受体 (CAR) 修饰的自然杀手 (NK) 细胞正在成为抵抗性癌症的有效治疗方法.
- 甲状腺刺激激素受体 (TSHR) 在DTC中表达,为治疗提供了特定的点.
研究的目的:
- 开发一种用于DTC的创新免疫疗法,使用针对TSHR的CAR修饰NK-92细胞.
- 评估这些工程NK细胞对DTC的疗效和安全性.
主要方法:
- 开发NK-92细胞,使用针对TSHR的CAR进行工程.
- 对DTC细胞系的修改NK细胞细胞毒性,脱粒化和细胞因子释放的评估.
- 在DTC的小鼠模型中对放射治疗的CAR-NK细胞的抗瘤疗效的评估.
主要成果:
- 用TSHR-CAR修饰的NK-92细胞显示增强了对TSHR阳性DTC细胞的杀死.
- 修改后的细胞表现出增加的脱粒和细胞因子的产生.
- 经辐射治疗的CAR-NK细胞停止了增殖,同时保持了强大的抗瘤活性,导致小鼠的显著瘤抑制.
结论:
- 用TSHR-CAR修饰的NK-92细胞代表了差异化甲状腺癌的强有力的治疗策略.
- 这种方法为DTC提供了一个有希望的,现成的,向免疫治疗的选择.
- 进一步开发CAR-NK细胞疗法有可能推进DTC治疗.
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