阿尔茨海默病的发病率和患有和没有喘的患病率:一个医疗保险队列研究
Christie M Bartels1, Yi Chen2, W Ryan Powell3
1Rheumatology Division, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis; Center for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, Madison, Wis.
The Journal of allergy and clinical immunology
|April 26, 2024
概括
喘增加了阿尔茨海默病 (AD) 的风险. 这项研究发现喘患者的AD发病率高出20-33%,患病率高出25-48%,这凸显了对风险途径的进一步研究的需要.
科学领域:
- 神经学 神经学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 越来越多的证据表明,炎症状况与阿尔茨海默病 (AD) 风险增加之间存在联系.
- 喘是一种普遍的炎症性疾病,可能会导致AD的发展.
研究的目的:
- 调查喘与阿尔茨海默病 (AD) 在美国人口中的发病率和流行率之间的联系.
- 探索潜在的风险路径和阿兹海默症在患有喘的人群中的缓解策略.
主要方法:
- 一项大规模的队列研究,使用2013-2015年美国医疗保险受益人的20%随机样本.
- 基于诊断断言的阿兹海默症发病率和患病率在患有和没有喘的成年患者之间进行比较.
- 喘和AD诊断是使用特定的国际疾病分类 (ICD) 代码来确定的.
主要成果:
- 该研究在超过540万受益者中确定了678,730名喘患者.
- 与没有喘的患者相比,喘患者的两年发病率 (1.4%对1.1%) 和患病率 (7.8%对5.4%) 较高 (P ≤ .001).
- 多变量分析表明,喘患者的AD发病率 (aOR 1.33) 和患病率 (aOR 1.48) 的几率显著增加.
结论:
- 喘与患上阿尔茨海默病 (AD) 的风险大幅增加有关.
- 研究结果表明,阿兹海默症发病率上升了20%至33%,阿兹海默症患病率上升了25%至48%.
- 需要进一步的研究,以了解潜在的并发症,社会决定因素和潜在的治疗干预措施,以保持喘患者的大脑健康.
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