Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

71
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
71
Human Genetics01:28

Human Genetics

564
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
564

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

In Utero PFAS Exposure, Inflammation, and Behavioral Problems in Childhood.

Environmental research·2026
Same author

Differentiating genetic and gene-environment interaction profiles of physical and mental health disorders.

Communications medicine·2026
Same author

How does maternal "belief in a dangerous world" affect maternal and child depressive symptoms during times of crisis?

Journal of affective disorders reports·2026
Same author

Prenatal metabolic adversity reprograms insulin-responsive transcription in the developing nucleus accumbens.

Molecular metabolism·2026
Same author

Prurigo nodularis en plaque resolved after a loading dose of nemolizumab.

Proceedings (Baylor University. Medical Center)·2026
Same author

Developing a multi-modal neuroimaging-based BrainAge model across childhood.

bioRxiv : the preprint server for biology·2026

相关实验视频

Updated: Jun 27, 2025

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice
07:15

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice

Published on: March 15, 2024

1.5K

微质功能与环境相互作用,影响性别特异性抑郁风险.

Eamon Fitzgerald1, Irina Pokhvisneva2, Sachin Patel2

  • 1Ludmer Centre for Neuroinformatics and Mental Health, McGill University, Canada; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Canada.

Brain, behavior, and immunity
|April 26, 2024
PubMed
概括

微质功能影响性别特异性抑郁风险,特别是在女性身上. 这项研究发现,微质多基因评分可以缓和女性抑郁风险因素和抑郁症状之间的联系.

关键词:
抑郁症 抑郁症 抑郁症遗传学 遗传学 是一个微质细胞中的微质细胞精神疾病 精神疾病风险因素 风险因素性差异性差异性差异性差异性差异性差异性差异性

更多相关视频

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice
05:28

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

Published on: May 15, 2019

22.2K
Chronic Social Defeat Stress in Early Adolescent Male Mice
07:06

Chronic Social Defeat Stress in Early Adolescent Male Mice

Published on: January 24, 2025

477

相关实验视频

Last Updated: Jun 27, 2025

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice
07:15

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice

Published on: March 15, 2024

1.5K
A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice
05:28

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

Published on: May 15, 2019

22.2K
Chronic Social Defeat Stress in Early Adolescent Male Mice
07:06

Chronic Social Defeat Stress in Early Adolescent Male Mice

Published on: January 24, 2025

477

科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 遗传学 是一个
  • 精神病学是一个精神病学.

背景情况:

  • 抑郁症对女性的影响率是男性的两倍.
  • 微质细胞,大脑中的免疫细胞,与性别依赖的抑郁风险有关.

研究的目的:

  • 调查微质功能与性别特异性抑郁风险之间的关系.
  • 确定微质遗传倾向是否与其他因素结合影响抑郁风险.

主要方法:

  • 使用了全基因组关联研究 (GWAS) 丰富,基因组丰富分析和门德尔随机化.
  • 微质功能的多基因分数 (PGS) 是从成人 (英国生物库) 和胎儿 (ALSPAC) 数据中生成的.
  • 微质PGS与抑郁症风险因素 (BMI,财务不安全,产前抑郁症) 之间的相互作用被分析为性别差异.

主要成果:

  • 微质和性别依赖性抑郁风险之间直接的遗传联系的证据很少.
  • 成年微质PGS调节了BMI和财务不安全与女性抑郁症状之间的关联.
  • 胎儿微质PGS调节了母亲产前抑郁症和女性后代抑郁症之间的关联.
  • 在男性中没有发现显著的相互作用.

结论:

  • 微质功能在赋予性别依赖性抑郁风险方面发挥着作用.
  • 在女性暴露于抑郁症风险因素后,观察到这种效应.
  • 这些发现突出了抑郁症病因学中潜在的性别特异性途径,涉及微质细胞.