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图像导向放射治疗用于治疗前列腺癌的治疗方法. 随机对照试验 (RIC-试验) 的5年结果

Jo-Åsmund Lund¹, Stian Lydersen², Bjørg Aksnessæther³

¹Clinic for Cancer Treatment and Rehabilitation, Helse Møre and Romsdal Hospital Trust, Ålesund, Norway; Department of Health Sciences, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Ålesund, Norway.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

|April 26, 2024

概括

使用每周2D或每天3D成像进行前列腺癌的图像指导放射治疗显示出类似的结果. 这两种方法都是安全有效的,在5年后,副作用或存活率没有显著差异.

科学领域:

辐射瘤学辐射瘤学
临床试验临床试验
前列腺癌治疗方法前列腺癌治疗方法

背景情况:

一项随机对照试验比较了前列腺癌患者每周的二维门户成像与每日的三维验证.
该研究的重点是评估图像指导放射治疗的临床结果.

研究的目的:

为了评估5年随访后的直肠和尿路副作用,生活质量和无进展生存率.
为了比较两个图像导向放射治疗技术在前列腺癌管理中的有效性和安全性.

主要方法:

260名患有中高风险前列腺癌的男性被随机分配为每周2D (A臂) 或每天3D圆束CT (B臂) 成像.
两组人都接受了78 Gy/39分数的放射治疗和激素治疗.
患者报告的结果 (肠道/尿道症状,生活质量) 和无进展生存率是初级和二级终点.

主要成果:

在216名患者中,超过90%的患者完成了5年的随访结果测量.
两只手臂之间在肠道或尿道症状或生活质量方面没有发现显著差异.
无进展生存时间相似,B臂与A臂的危险比为1.01 (95% CI 0.57-1.97).

结论:

每周2D和每天3D图像导向放射治疗都是安全有效的前列腺癌治疗方法.
这些发现强调了长期跟踪在评估放射治疗技术进步方面的重要性.
两种图像指导策略之间没有发现显著的临床结果差异.

关键词:

IGRTT 在线观看晚期的副作用晚期的副作用前列腺癌是什么意思前列腺癌是什么意思辐射疗法辐射疗法随机试验是指随机的试验.

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