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评估疲劳及其对慢性肝病的影响
Zobair M Younossi1, Andreas E Kremer2, Mark G Swain3
1Beatty Liver and Obesity Research Program, Inova Health System, Falls Church, VA, USA; The Global Liver Council, Washington DC, USA.
Journal of hepatology
|April 26, 2024
概括
患者报告的结果,如与健康相关的生活质量 (HRQL),对于慢性肝病 (CLD) 至关重要. 疲劳显著影响CLD患者的HRQL,需要PRO数据进行全面的负担评估和治疗评估.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 患者报告的结果
- 临床研究 临床研究
背景情况:
- 患者报告结果 (PROs),包括与健康相关的生活质量 (HRQL),对于评估慢性肝病患者至关重要.
- 疲劳是CLD的常见症状,无论疾病严重程度如何,都会影响患者,并显著损害PROs.
- 肝硬化和晚期肝病与减少HRQL和增加疲劳有关.
研究的目的:
- 提供有关初级胆道胆炎,C型肝炎病毒和代谢功能障碍相关的脂肪性肝病 (MASLD) 患者疲劳和HRQL的专家评价.
- 阐明疲劳的复杂性质,包括外围和中心原因.
- 强调PRO数据对于了解CLDs的全部影响的重要性.
主要方法:
- 一个专门研究疲劳和CLD的专家小组审查和综合了现有的文献.
- 专家之间的讨论和协作,以制定一个全面的审查.
- 分析与疲劳和HRQL测量以及特定CLD中的影响相关的概念.
主要成果:
- 疲劳是一种多方面的症状,其来源是外围 (神经肌肉,心肺呼吸系统) 和中央 (中枢神经系统功能障碍).
- HRQL和疲劳是通过验证的自我报告仪器和客观测试,如握力等测量.
- 虽然治疗C型肝炎病毒和MASLD可以改善疲劳和HRQL,但初级胆道胆炎治疗目前对疲劳没有影响.
结论:
- 疲劳对CLD患者的HRQL,体力活动和社会参与有负面影响,与疾病严重程度没有一致的相关性.
- 获取PRO数据,特别是关于疲劳和HRQL的数据,对于评估CLD的综合负担至关重要.
- PRO数据对于指导和评估潜在的CLD治疗疗法的有效性至关重要.
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