阿德罗可以通过改善成年老鼠的抗氧化剂潜力来调节卵巢功能
Shweta Maurya1, Shashank Tripathi1, Taruna Arora2
1Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi 221005, India.
The Journal of steroid biochemistry and molecular biology
|April 26, 2024
概括
氨酸通过促进孕激素的产生和减少氧化应激来增强黄体 (CL) 功能. 这种在改善CL存活率方面表现有前途,这对于维持妊娠至关重要.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 分子生物学分子生物学
背景情况:
- 黄体 (CL) 对于孕激素合成至关重要,对于雌激素周期调节,植入和怀孕维持至关重要.
- 之前的研究已经在白质细胞中确定了阿德罗宾及其受体GPR19,这表明它在白质化中起着作用.
研究的目的:
- 为了研究adropin在成年小鼠hCG诱导的卵巢功能的体外影响.
- 评估外源性阿德罗宾对卵巢类固醇生成和抗氧化剂参数的影响,重点关注CL功能.
主要方法:
- 在体外评估阿德罗宾对hCG刺激的卵巢细胞的影响.
- 向小鼠给予外源性阿德罗宾,以分析卵巢类固醇生成和抗氧化剂标志物.
- 测量蛋白质表达 (StAR,3β-HSD,芳酶),亡标志物 (BAX/BCL2比率,卡斯帕酶3),氧化应激标志物 (NRF-2,HO-1,SOD,甲酶,脂质过氧化) 和道测定.
主要成果:
- 氨酸与hCG协同作用,通过上调StAR,3β-HSD和芳酶,并降低BAX/BCL2比率来促进类固醇生成和细胞存活.
- 外源性阿德罗通过GPR19,StAR和3β-HSD增加了孕激素的产生.
- 亚德罗宾通过促进NRF-2核转位,增加HO-1,SOD和催化酶活性,并降低亡标志物来降低质氧化应激.
结论:
- 阿德罗可以增强卵巢类固醇生成和质细胞存活率,可能通过抑制氧化应激和亡.
- 阿德罗显示出作为治疗剂的潜力,可以改善红体的生存能力.
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