在风湿性免疫相关不良事件中成像
Jeremy Zhang1, Ruoning Ni2, Ibiyemi Oke2
1Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, C310 GH, Iowa City, IA 52242-1009, USA.
Rheumatic diseases clinics of North America
|April 26, 2024
概括
免疫检查点抑制剂可以引起影响肌肉骨系统的免疫相关不良事件 (irAEs). 本综述探讨了用于诊断和监测这些类风湿性IRAE的成像技术,从而改善患者护理.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 放射学 放射学是一门学科.
背景情况:
- 免疫检查点抑制剂 (ICI) 通过激活免疫系统,改变了癌症治疗.
- 通过ICI激活免疫系统可能导致与免疫相关的不良事件 (irAEs).
- 影响肌肉骨系统的类风湿性IRAE并不常见,但可能导致显著的疼痛和残疾.
研究的目的:
- 审查目前关于用于诊断风湿性IRAE的成像方法的文献.
- 评估成像在监测这些IRE的治疗反应中的作用.
- 为管理ICI肌肉骨并发症提供见解.
主要方法:
- 系统的文献搜索报告在风湿性IRAE成像研究的研究.
- 分析与ICI相关的各种肌肉骨疾病的成像发现.
- 评估成像在评估治疗疗效方面的实用性.
主要成果:
- 各种成像技术,包括MRI,超声波和PET扫描,在诊断风湿性IRAE方面表现有前途.
- 图像检查可以帮助区分irAEs与其他疾病,并评估疾病活动.
- 特定的成像模式与不同类型的风湿性IRAE有关.
结论:
- 图像在诊断和治疗风湿性IRAE中起着至关重要的作用.
- 需要进一步的研究来标准化成像协议并验证其预后价值.
- 优化成像策略可以改善ICI癌症患者的治疗结果和生活质量.
相关概念视频
Imaging Studies for Cardiovascular System III: X-Ray
180
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
180
Imaging Studies for Cardiovascular System I:Echocardiography
319
Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
319
Imaging Studies I: CT and MRI
238
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
238
X-ray Imaging
5.5K
German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
5.5K
Ultrasonography
4.5K
Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...
During an ultrasonography procedure, a handheld device called...
4.5K
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
160
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
160


