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Updated: Jun 27, 2025

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KLF15-Cyp3a11轴调节里芬素诱导的肝损伤

Wanqing Hou1, Ku-Geng Huo1, Xiaohua Guo1

  • 1Department of Hepatobiliary Surgery, Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China (W.H., X.G.); Cyagen Biosciences (Guangzhou) Inc. Guangzhou, Guangdong, China (K.-G.H.); Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi, China (M.X., Y.Y., Z.S., J.T., Z.M., S.H.); Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (W.X.); and Lantu Biopharma, Guangzhou, China (T.G.).

Drug metabolism and disposition: the biological fate of chemicals
|April 26, 2024
PubMed
概括

克鲁佩尔样因子15 (KLF15) 调节了里芬素 (RFP) 的排毒. 抑制KLF15可以增强RFP排毒酶Cyp3a11,减少肝损伤并恢复小鼠的功能.

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