Sprouty1是细胞衰老的广泛调解者
Carlos Anerillas1,2,3, Aida Perramon-Güell4, Gisela Altés4
1Developmental and Oncogenic Signaling Group, Universitat de Lleida/Institut de Recerca Biomèdica de Lleida, Rovira Roure, 80, Lleida, Spain. canerillas@cbm.csic.com.
Cell death & disease
|April 26, 2024
概括
芽蛋白调解细胞衰老,这是一个关键的衰老过程. Sprouty 基因的升级会触发过早衰老,影响小鼠的伤口愈合和化疗反应.
科学领域:
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
- 遗传学 是一个遗传学.
背景情况:
- 芽基因 (Spry1-4) 调节受体氨酸激酶信号传递.
- 这些基因对发育至关重要,并充当瘤抑制剂.
- 果芽蛋白的精确生物功能仍然不完全理解.
研究的目的:
- 为了研究Sprouty蛋白在细胞衰老中的作用.
- 阐明Sprouty蛋白质影响衰老的分子机制.
- 为了检查Sprouty介导衰老的体内相关性.
主要方法:
- 在体外使用各种触发器诱导细胞衰老.
- 过度表达Sprouty基因和分析衰老标志物的分析.
- 产生和分析具有关键 Sprouty 氨酸残留物突变的诺金小鼠.
- 在体内伤口愈合和化疗期间评估衰老.
主要成果:
- 细胞衰老诱导与增加的Sprouty蛋白水平相关.
- 芽基因过度表达导致过早衰老,依赖于特定的N-终端氨酸.
- 缺乏这种氨酸的诺金纤维细胞抵抗复制性衰老.
- 在体内研究表明,在伤口愈合期间和化疗后,异构卵性诺金小鼠的衰老延迟.
- 芽诱导的衰老是独立于ERK1/2的,但在p38通路上游起作用.
结论:
- 芽蛋白被认为是细胞衰老的一般调解者.
- 在Sprouty蛋白质中,一种特定的氨酸残留物对于诱导衰老至关重要.
- 芽介导的衰老独立于ERK1/2通路运行,涉及p38通路.
- 这些发现揭示了Sprouty蛋白在衰老和压力反应中的新角色.
相关概念视频
Mitochondria
12.3K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
12.3K
Cell Signaling in Plants
5.6K
Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
5.6K
Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
Cells Coordinate Growth and Proliferation
4.5K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
4.5K
Molecular Factors Affecting Cell Division
3.1K
Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
3.1K
Renewal of Intestinal Stem Cells
2.6K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.6K


