在物理治疗中Hippo/YAP信号通路的作用
Chunran Pan1, Xiaoxia Hao1, Xiaofeng Deng1
1Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Cell death discovery
|April 26, 2024
概括
物理治疗方法通过机械信号影响细胞行为. 河马/YAP通路作为一个关键的分子机制,翻译这些信号来调节基因表达和治疗疾病.
科学领域:
- 生物物理学的生物物理.
- 细胞生物学 细胞生物学
- 分子医学是分子医学.
背景情况:
- 细胞行为和疾病发展受到微环境的机械信号的影响,包括温度,血流和肌肉收缩.
- 物理治疗模式,如超声波,振动,运动和热疗法在临床上用于缓解疼痛和治疗疾病.
- 这些物理疗法调节细胞反应和基因表达的精确分子机制在很大程度上仍未定义.
研究的目的:
- 审查Hippo/YAP信号通路在各种疾病中的参与.
- 检查Hippo/YAP通路在疾病治疗的物理治疗方法中的作用.
- 探索在物理治疗中准Hippo/YAP途径的治疗潜力和局限性.
主要方法:
- 对Hippo/YAP信号通路研究的文献综述.
- 分析将机械信号,细胞反应和疾病联系在一起的研究.
- 检查物理治疗技术及其分子基础.
主要成果:
- 河马/YAP通道作为机械信号的关键传感器和传感器.
- YAP (YES相关蛋白) 将机械刺激转化为转录程序.
- 这种途径为物理疗法如何影响组织和基因表达提供了新的机制解释.
结论:
- 河马/YAP通路为了解物理治疗对细胞行为和疾病的影响提供了一个分子框架.
- 准Hippo/YAP通路为通过物理治疗治疗的各种疾病提供了潜在的治疗策略.
- 需要进一步的研究来充分阐明和利用治疗含义,并解决围绕其在物理治疗中的应用引起的争议.
相关概念视频
Hedgehog Signaling Pathway
7.3K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
7.3K
The JAK-STAT Signaling Pathway
8.8K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.8K
PI3K/mTOR/AKT Signaling Pathway
3.5K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.5K
Interactions Between Signaling Pathways
6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K
Regulation of Angiogenesis and Blood Supply
2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
Role of Matrix Metalloproteases in Degradation of ECM
2.4K
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
2.4K


