一个集群随机试验的水,卫生,洗手和营养干预措施的压力和表观遗传编程
Audrie Lin1, Andrew N Mertens2, Md Ziaur Rahman3
1Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, CA, USA. audrielin@ucsc.edu.
Nature communications
|April 26, 2024
概括
综合营养和卫生干预改善了儿童的生理应激反应. 这项在孟加拉国的研究发现,在接受N+WSH干预的儿童中,氧化压力降低,压力调节提高.
科学领域:
- 环境健康 环境健康
- 发育儿科 发育儿科
- 分子生物学分子生物学
背景情况:
- 调节的应激反应对于健康的儿童发育至关重要.
- 早期的生活压力可能会对长期健康轨迹产生负面影响.
- 综合干预可能是缓解早期生活压力的有希望的方法.
研究的目的:
- 评估综合营养,水,卫生和洗手 (N+WSH) 干预措施对幼儿生理压力标志物的影响.
- 调查干预对氧化应激和DNA甲基化的影响.
- 评估幼儿时期生理压力系统的适应性反应.
主要方法:
- 孟加拉农村的集群随机试验,涉及759名1-2岁儿童.
- 干预组接受了营养咨询,补充剂,化水,改善卫生条件和洗手教育.
- 测量了F2-异质,唾液皮质醇,α-氨酶和NR3C1基因促进物甲基化.
主要成果:
- 在N+WSH组中,F2-异质素 (氧化应激标志物) 的度较低.
- 在干预组中观察到高压后皮质醇和较高的残留增益得分.
- 观察到NR3C1基因促进体中NGFI-A结合部位的甲基化减少.
结论:
- 综合N+WSH干预积极调节幼儿的生理应激反应.
- 研究结果表明,氧化应激和应激系统调节的改善.
- 这种干预可以增强适应性应激反应,支持健康的儿童发育.
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