光学连贯性断层扫描血管学分析方法:一个系统的审查和元分析
Ella Courtie1,2,3, James Robert Moore Kirkpatrick4, Matthew Taylor5,6,7
1Neuroscience and Ophthalmology Research Group, University of Birmingham, Birmingham, UK.
Scientific reports
|April 26, 2024
概括
视网膜 perfusion 的光学连贯性断层扫描血管学 (OCTA) 方法有很大的差异. 本综述强调了OCTA技术的广泛异质性,强调了视网膜血管成像研究中需要标准化的方法.
科学领域:
- 眼科医生 眼科 眼科
- 医疗成像医学成像
- 血管生物学 血管生物学
背景情况:
- 光学连贯断层扫描血管造影 (OCTA) 是用于视网膜血管成像的关键非侵入性工具.
- 目前OCTA评估视网膜输液的方法在研究中表现出相当大的差异.
- 这种变化使研究结果的解释和比较变得复杂.
研究的目的:
- 系统地评估和描述在OCTA研究中用于评估视网膜输液的各种方法.
- 为了确定在视网膜血管成像中使用的OCTA技术中异质性的程度.
- 提供支持OCTA方法论标准化需要的证据.
主要方法:
- 从2014年到2021年8月,对MEDLINE和Embase数据库进行了全面的文献搜索.
- 包括使用OCTA评估视网膜 perfusion 在全球视网膜或系统性疾病的前性研究,参与者≥50人.
- 用既有统计工具和质量评估框架来评估偏差风险和数据异质性.
主要成果:
- 在5974项确定的研究中,包括了191项,揭示了197种不同的评估斑点 perfusion 的方法,这些方法来自设备,体积尺寸,子区域,分析和血管层的组合.
- 对88项研究的元分析显示,与对照组相比,糖尿病患者的视网膜输液减少,尽管异质性很高.
- 在评估表面毛细管时,异质性最低,血管影响最明显.
结论:
- 系统审查表明OCTA在视网膜输液评估方法中的巨大异质性.
- 这些发现强烈支持迫切需要对OCTA方法的标准化,以提高研究的一致性和临床适用性.
- 标准化的OCTA协议对于可靠的视网膜血管成像和在各种眼部和全身条件下精确评估输液至关重要.
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