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Updated: Jun 27, 2025

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
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Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

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双胺缺乏促进了eEF2与p53的结合,从而诱导p21表达和神经缺陷

Yu Shi1,2, Daochao Huang3, Cui Song4

  • 1Department of Clinical Laboratory, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, 136 Zhongshan 2nd Rd, Chongqing, 400014, China. shiyu@hospital.cqmu.edu.cn.

Nature communications
|April 26, 2024
PubMed
概括

在真核细胞翻译延长因子2 (eEF2) 上的二甲胺基修饰对于发育至关重要. 它的损失通过将eEF2与p53和p21表达联系起来,损害了神经细胞的增殖.

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An Explant Assay for Assessing Cellular Behavior of the Cranial Mesenchyme07:45

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Abnormal Proliferation02:23

Abnormal Proliferation

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